ArticlePediatric nephrology (Berlin, Germany)2018
Presentation of pediatric Henoch-Schönlein purpura nephritis changes with age and renal histology depends on biopsy timing.
Article in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Correlation between the course of kidney injury and clinicopathology and prognosis of children with Henoch-Schönlein purpura nephritis.International urology and nephrology · 2025Article
- Outcome of children with IgA vasculitis with nephritis treated with steroids: a matched controlled study.Pediatric nephrology (Berlin, Germany) · 2023Observational
- Early clinical course of biopsy-proven IgA vasculitis nephritis.BMC pediatrics · 2022Article
- Comparison of clinical, pathological and long-term renal outcomes of children with Henoch-Schonlein purpura nephritis and IgA nephropathy.International urology and nephrology · 2022Article
- IgA vasculitis with nephritis: update of pathogenesis with clinical implications.Pediatric nephrology (Berlin, Germany) · 2022Review
- Association of the clinicopathological characteristics and proteinuria remission of pediatric IgAV with nephrotic-range proteinuria: A retrospective cohort study.Frontiers in pediatrics · 2022Article
- A retrospective study on the characteristics of renal pathological grades in HSPN children with mild to moderate proteinuria.Frontiers in pediatrics · 2022Article
- Association of kidney biopsy findings with short- and medium-term outcomes in children with moderate-to-severe IgA vasculitis nephritis.European journal of pediatrics · 2021Article
- Management of IgA Vasculitis with Nephritis.Paediatric drugs · 2021Review
- IgA vasculitis nephritis in children and adults: one or different entities?Pediatric nephrology (Berlin, Germany) · 2021Review
- The Efficacy ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Clinical effect of combined western medicine and traditional Chinese medicine on children with Henoch-Schönlein purpura nephritis.American journal of translational research · 2021Article
- Analysis of Nursing Effect of Children with Henoch-Schonlein Purpura Based on the PDCA Nursing Model.Computational and mathematical methods in medicine · 2021Article
- Histological prognostic factors in children with Henoch-Schönlein purpura nephritis.Pediatric nephrology (Berlin, Germany) · 2020Article
- A clinicopathological comparison between IgA nephropathy and Henoch-Schönlein purpura nephritis in children: use of the Oxford classification.Clinical and experimental nephrology · 2019Article
- Methylprednisolone or cyclosporine a in the treatment of Henoch-Schönlein nephritis: a nationwide study.Pediatric nephrology (Berlin, Germany) · 2019Article
- Differential expression of long non-coding RNA and mRNA in children with Henoch-Schönlein purpura nephritis.Experimental and therapeutic medicine · 2019Article
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31 authors.
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Abstract
backgroundThis study correlates the clinical presentation of Henoch-Schönlein purpura nephritis (HSPN) with findings on initial renal biopsy.
methodsData from 202 pediatric patients enrolled in the HSPN registry of the German Society of Pediatric Nephrology reported by 26 centers between 2008 and 2014 were analyzed. All biopsy reports were re-evaluated for the presence of cellular crescents or chronic pathological lesions (fibrous crescents, glomerular sclerosis, tubular atrophy >5%, and interstitial fibrosis >5%).
resultsPatients with HSPN with cellular glomerular crescents were biopsied earlier after onset of nephritis (median 24 vs 36 days, p = 0.04) than those without, whereas patients with chronic lesions were biopsied later (57 vs 19 days, p < 0.001) and were older (10.3 vs 8.6 years, p = 0.01) than those without. Patients biopsied more than 30 days after the onset of HSPN had significantly more chronic lesions (52 vs 22%, p < 0.001), lower eGFR (88 vs 102 ml/min/1.73m
conclusionsIn summary, we find an age-dependent presentation of HSPN with a more insidious onset of non-nephrotic proteinuria, impaired renal function, longer delay to biopsy, and more chronic histopathological lesions in children above the age of 10 years. Thus, HSPN presents more like Immunoglobulin A (IgA) nephritis in older than in younger children.
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