ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2017
Signal reduction in choriocapillaris and segmentation errors in spectral domain OCT angiography caused by soft drusen.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Clinical Use of Optical Coherence Tomography Angiography in Retinal Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Effects of smoking on the retina of patients with dry age-related macular degeneration by optical coherence tomography angiography.BMC ophthalmology · 2022Article
- Associations between Choriocapillaris Flow on Optical Coherence Tomography Angiography and Cardiovascular Risk Profiles of Patients with Acute Myocardial Infarction.Journal of personalized medicine · 2022Article
- Retinal Vessel Density in Age-Related Macular Degeneration Patients with Geographic Atrophy.Journal of clinical medicine · 2022Article
- Assessment of Artifacts in Swept-Source Optical Coherence Tomography Angiography for Glaucomatous and Normal Eyes.Translational vision science & technology · 2022Article
- Comparison of Optical Coherence Angiography Measurements in Patients with Neovascular and Non-Neovascular Age-Related Macular Degeneration.Sisli Etfal Hastanesi tip bulteni · 2022Article
- Geographic Atrophy Progression Is Associated With Choriocapillaris Flow Deficits Measured With Optical Coherence Tomographic Angiography.Investigative ophthalmology & visual science · 2021Article
- Longitudinal choriocapillaris changes in the presence of reticular pseudodrusen.Scientific reports · 2021Article
- Segmentation Errors in the Measurement of Volumetric Parameters by Swept-Source Anterior Segment Optical Coherence Tomography.Frontiers in medicine · 2021Article
- Retinal Vessel Density in Exudative and Nonexudative Age-Related Macular Degeneration on Optical Coherence Tomography Angiography.American journal of ophthalmology · 2020Article
- Automated OCT angiography image quality assessment using a deep learning algorithm.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Article
- [Optical coherence tomography angiography: Value for glaucoma diagnostics].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019Review
- Optical coherence tomography angiography image quality assessment at varying retinal expertise levels.Journal of current ophthalmology · 2019Article
- Retinal pigment epithelium hyperplasia overlying pigment epithelial detachment in age-related macular degeneration can masquerade as neovascularization on optical coherence tomography angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Article
- Prevalences of segmentation errors and motion artifacts in OCT-angiography differ among retinal diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Article
- Choriocapillaris Vascular Density Changes in Patients with Drusen: Cross-Sectional Study Based on Optical Coherence Tomography Angiography Findings.Ophthalmology and therapy · 2018Article
- Choriocapillaris changes in dry age-related macular degeneration and geographic atrophy: a review.Eye and vision (London, England) · 2018Review
- Measurement of the Inner Macular Layers for Monitoring of Glaucoma: Confounding Effects of Age-Related Macular Degeneration.Ophthalmology. GlaucomaObservational
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyze signal reduction in choriocapillaris (CC) and segmentation errors in spectral domain optical coherence tomography angiography (OCT-A) caused by soft drusen due to age-related macular degeneration (AMD).
methodsTwenty-four eyes of 24 patients underwent multimodal retinal imaging including central 3 × 3mm
resultsMean drusen height and diameter were 91.57 ± 19.5μm and 315.17 ± 116.7μm. OCT-A layer segmentation of the inner plexiform layer (IPL) was disturbed by more than 50 μm in proximity to 26 drusen (36.1%). In these patients, drusen height was significantly higher compared to those with accurate IPL segmentation (p = 0.0126). Sixty-six out of 72 drusen (91.7%) caused a distinct signal loss in the structural en-face OCT CC image. Drusen height and drusen diameter were significantly higher in this group compared to the six drusen with a sufficient signal (p = 0.0276, p = 0.0025). CC decorrelation signal index measured in the area of these six drusen without OCT signal loss (8.3%) was reduced compared to age-matched healthy controls (73.6 vs. 100.1; p = 0.001).
conclusionsSignal attenuation in CC slabs and segmentation errors of the IPL depend on drusen morphology. Both are frequent artifacts in OCT-A imaging in patients with soft drusen and must be considered during image analysis.
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