Evidence map›Paper›PMID 28983694›Full record

ArticlePediatric nephrology (Berlin, Germany)2018

Incomplete vaccination coverage in European children with end-stage kidney disease prior to renal transplantation.

Britta Höcker, Martin Aguilar, Paul Schnitzler, Lars Pape, Luca Dello Strologo, Nicholas J A Webb, Martin Bald, Gurkan Genc, Heiko Billing, Jens König and 11 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 14 institutions in 4 countries.

Britta HöckerDepartment of Paediatrics I, University Children's Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.ORCID 0000-0003-4131-2273
Martin AguilarDepartment of Paediatrics I, University Children's Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.
Paul SchnitzlerDepartment of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany.
Lars PapeHanover Medical School, Carl-Neuberg-Strasse 1, 30625, Hanover, Germany.
Luca Dello StrologoIRCCS Ospedale Pediatrico Bambino Gesù, Piazza di Sant'Onofrio 4, 00165, Rome, Italy.
Nicholas J A WebbRoyal Manchester Children's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, M13 9WL, Manchester, UK.
Martin BaldClinic of Stuttgart, Olga Children's Hospital, Kriegsbergstrasse 62, 70174, Stuttgart, Germany.
Gurkan GencPaediatric Nephrology Department, Ondokuz Mayis University Faculty of Medicine, Children's Hospital, Kurupelit, 55139, Samsun, Turkey.
Heiko BillingUniversity Children's Hospital, Hoppe-Seyler-Strasse 1, 72076, Tübingen, Germany.
Jens KönigDepartment of General Paediatrics, Paediatric Nephrology, University Children's Hospital, Waldeyerstrasse 22, 48149, Münster, Germany.
Anja BüscherUniversity Children's Hospital, Hufelandstrasse 55, 45122, Essen, Germany.
Markus J KemperUniversity Children's Hospital, Martinistrasse 52, 20246, Hamburg, Germany.
Stephen D MarksDepartment of Paediatric Nephrology, Great Ormond Street Hospital, Great Ormond Street Hospital for Children NHS Foundation Trust, WC1N 3JH, London, UK.
Martin PohlDepartment of General Pediatrics, Adolescent Medicine and Neonatology, Center for Pediatrics, Medical Center, Faculty of Medicine, University of Freiburg, Mathildenstrasse 1, 79106, Freiburg, Germany.
Marianne WiggerPaediatric Nephrology, University Children's Hospital, Ernst-Heydemann-Strasse 8, 18057, Rostock, Germany.
Rezan TopalogluDepartment of Paediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Susanne RiegerDepartment of Paediatrics I, University Children's Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.
Kai KrupkaDepartment of Paediatrics I, University Children's Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.
Thomas BrucknerInstitute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany.
Alexander FichtnerDepartment of Paediatrics I, University Children's Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.
Burkhard TönshoffDepartment of Paediatrics I, University Children's Hospital, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany. burkhard.toenshoff@med.uni-heidelberg.de.
Heidelberg University · DEBambino Gesù Children's Hospital · ITGreat Ormond Street Hospital for Children NHS Foundation Trust · GBHacettepe University · TRKinderkrebs-Zentrum Hamburg · DEManchester Academic Health Science Centre · GBMedizinische Hochschule Hannover · DEOlgahospital · DEOndokuz Mayıs University · TRUniversity Children's Hospital Tübingen · DEUniversity Hospital Münster · DEUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Freiburg · DEUniversity of Rostock · DE

Funding

Astellas Pharma Europe CERTAIN RegistryDietmar Hopp Stiftung CERTAIN RegistryNovartis Pharma CERTAIN Registry
6 · The paper itself

Abstract

backgroundBecause infections constitute a major cause of morbidity and mortality in paediatric renal allograft recipients, avoidance of preventable systemic infections by vaccination before transplantation is of utmost importance. However, data on the completeness of vaccinations and factors associated with incomplete vaccination coverage are scarce.

methodsWithin the framework of the Cooperative European Paediatric Renal Transplant Initiative (CERTAIN), we therefore performed a multi-centre, multi-national, retrospective study investigating the vaccination coverage before transplantation of 254 European children with end-stage renal disease (mean age 10.0 ± 5.6 years).

resultsOnly 22 out of 254 patients (8.7%) presented complete vaccination coverage. In particular, the respective vaccination coverage against human papillomavirus (27.3%), pneumococci (42.0%), and meningococci (47.9%) was low. Patients with complete pneumococcal vaccination coverage had numerically less lower respiratory tract infections during the first 3 years post-transplant than children without vaccination or with an incomplete status (16.4% vs 27.7%, p = 0.081). Vaccine-preventable diseases post-transplant were 4.0 times more frequently in unvaccinated than in vaccinated patients. Factors associated with an incomplete vaccination coverage were non-Caucasian ethnicity (OR 9.21, p = 0.004), chronic dialysis treatment before transplantation (OR 6.18, p = 0.001), and older age at transplantation (OR 1.33, p < 0.001).

conclusionsThe vaccination coverage in paediatric kidney transplant candidates is incomplete. Paediatric nephrologists, together with primary-care staff and patients' families, should therefore make every effort to improve vaccination rates before kidney transplantation.

Indexed as

Kidney Failure, ChronicKidney TransplantationAdolescentChildChild, PreschoolEuropeFemaleHumansMaleRetrospective StudiesVaccinationEnd-stage kidney diseasePaediatric transplant candidatePost-transplant lower respiratory tract infectionsRenal transplantationVaccination

Identifiers

PMID28983694
OpenAlexW2763902865

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.