ArticleClinical neuroradiology2019
In vivo Metabolic Profiles as Determined by
Article in Clinical neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Optimized Long-TEJournal of magnetic resonance imaging : JMRI · 2025Article
- Amino acid metabolism in glioma: in vivo MR-spectroscopic detection of alanine as a potential biomarker of poor survival in glioma patients.Journal of neuro-oncology · 2024Article
- Could Phosphorous MR Spectroscopy Help Predict the Severity of Vasospasm? A Pilot Study.Diagnostics (Basel, Switzerland) · 2024Article
- Whole-Brain Intracellular pH Mapping of Gliomas Using High-ResolutionRadiology. Imaging cancer · 2024Article
- Magnetic Resonance Spectroscopy in Diagnosis and Follow-Up of Gliomas: State-of-the-Art.Cancers · 2022Review
- Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations.Cell reports. Medicine · 2021Review
- Changes in Brain Energy and Membrane Metabolism in Glioblastoma following Chemoradiation.Current oncology (Toronto, Ont.) · 2021Article
- PCA denoising and Wiener deconvolution ofMagnetic resonance in medicine · 2021Article
- Clinical Applications of Magnetic Resonance Spectroscopy in Brain Tumors: From Diagnosis to Treatment.Radiologic clinics of North America · 2021Review
- Main genetic differences in high-grade gliomas may present different MR imaging and MR spectroscopy correlates.European radiology · 2021Article
- Mapping an Extended Metabolic Profile of Gliomas Using High-ResolutionFrontiers in neurology · 2021Article
- Lower Lactate Levels and Lower Intracellular pH in Patients withAJNR. American journal of neuroradiology · 2020Article
- Magnetic resonance spectroscopy of isocitrate dehydrogenase mutated gliomas: current knowledge on the neurochemical profile.Current opinion in neurology · 2020Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePrevious ex vivo spectroscopic data from tissue samples revealed differences in phospholipid metabolites between isocitrate dehydrogenase mutated (IDHmut) and IDH wildtype (IDHwt) gliomas. We investigated whether these changes can be found in vivo using
methodsThe study included 33 prospectively enrolled, mostly untreated patients who met spectral quality criteria according to the World Health Organization (WHO II n = 7, WHO III n = 17, WHO IV n = 9; 25 patients IDHmut, 8 patients IDHwt). The MRSI protocol included
resultsIn our patient cohort we did not find significant differences for the ratio of phosphocholine (PC) and phosphoethanolamine (PE), PC/PE, (p = 0.24) for IDHmut compared to IDHwt gliomas. Furthermore, we found no elevated ratios of glycerophosphocholine (GPC) and glycerophosphoethanolamine (GPE), GPC/GPE, (p = 0.68) or GPC/PE (p = 0.12) for IDHmut gliomas. Even the ratio (PC+GPC)/(PE+GPE) showed no significant differences with respect to mutation status (p = 0.16). Nonetheless, changes related to tumor grade regarding intracellular pH (pH
conclusionUsing 3D-CSI data acquisition, in vivo
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