Evidence map›Paper›PMID 28983602›Full record

ArticleMolecular medicine reports2017

The role of TGFβ‑HGF‑Smad4 axis in regulating the proliferation of mouse airway progenitor cells.

Xue Li, Li Yang, Xin Sun, Junping Wu, Yu Li, Qiuyang Zhang, Yingchao Zhang, Kuan Li, Qi Wu, Huaiyong Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Xue LiDepartment of Basic Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, P.R. China.
Li YangDepartment of Respiratory Medicine, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
Xin SunKey Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin 300350, P.R. China.
Junping WuKey Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin 300350, P.R. China.
Yu LiDepartment of Basic Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, P.R. China.
Qiuyang ZhangDepartment of Basic Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, P.R. China.
Yingchao ZhangRespiratory Department, Baodi Clinical College of Tianjin Medical University, Tianjin 301800, P.R. China.
Kuan LiDepartment of Basic Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, P.R. China.
Qi WuDepartment of Basic Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, P.R. China.
Huaiyong ChenDepartment of Basic Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, P.R. China.
Tianjin Medical University · CNState Administration of Traditional Chinese Medicine of the People's Republic of China · CNTianjin Medical University General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interaction between airway epithelial progenitor cells and their microenvironment is critical for maintaining lung homeostasis. This microenvironment includes fibroblast cells, which support the growth of airway progenitor cells. However, the mechanism of this support is not fully understood. In the present study, the authors observed that inhibition of transforming growth factor (TGF)‑β signal with SB431542 promotes the expression of hepatocyte growth factor (HGF) in fibroblast cells. The HGF receptor, c‑Met, is expressed on airway progenitor cells; HGF promotes the colony‑forming ability of airway progenitor cells. The deletion of Smad4 in airway progenitor cells increases the colony‑forming ability, suggesting that Smad4 plays a negative role in the regulating the proliferation of airway progenitor cells. These data demonstrated that the regulation of airway progenitor cells by TGF‑β depends on TGF‑βR1/2 on stromal cells, rather than on epithelial progenitor cells. These data suggested a role for the TGF‑β‑TGF‑βR1/2‑HGF‑Smad4 axis in airway epithelial homeostasis and sheds new light on the interaction between airway progenitor cells and their microenvironment.

Indexed as

Signal TransductionAlveolar Epithelial CellsAnimalsCell ProliferationComputational BiologyFibroblastsGene Expression ProfilingHepatocyte Growth FactorMiceModels, BiologicalMolecular Sequence AnnotationProto-Oncogene Proteins c-metRespiratory MucosaSmad4 ProteinStem CellsTranscriptomeHepatocyte Growth FactorProto-Oncogene Proteins c-metSmad4 ProteinTransforming Growth Factor beta

Identifiers

PMID28983602
PMCPMC5779903
OpenAlexW2757158471

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.