ArticleACS omega2017
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit
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Article in ACS omega, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Synthesis and anti-antileishmanial profile of novel thiazolidine-4-one derivatives and molecular docking and molecular dynamics simulations studies.Scientific reports · 2026Article
- Exploring Novel Nitrofuryl-1,3,4-Thiadiazole-Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity.Archiv der Pharmazie · 2026Article
- Pathogenic Significance of Trypanosomatids: Progress in Drug Resistance, Control Strategies, and Artificial Intelligence.Interdisciplinary perspectives on infectious diseases · 2026Review
- Synthesis and characterization of FeCuAlOScientific reports · 2025Article
- Design of 2-Aminobenzothiazole Derivatives Targeting Trypanosomatid PTR1 by a Multidisciplinary Fragment Hybridization Approach.Journal of medicinal chemistry · 2025Article
- Antimicrobial Activity of 1,3,4-Thiadiazole Derivatives.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Synthesis and Anti-Molecules (Basel, Switzerland) · 2024Article
- High-Throughput Phenotypic Screening and Machine Learning Methods Enabled the Selection of Broad-Spectrum Low-Toxicity Antitrypanosomatidic Agents.Journal of medicinal chemistry · 2023Article
- Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.Journal of medicinal chemistry · 2022Article
- Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADPActa crystallographica. Section F, Structural biology communications · 2022Article
- Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases.Pharmaceuticals (Basel, Switzerland) · 2021Article
- A Novel Approach to the Synthesis of 1,3,4-Thiadiazole-2-amine Derivatives.Molecules (Basel, Switzerland) · 2021Article
- Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors ofPharmaceuticals (Basel, Switzerland) · 2021Article
- Toward Chemical Validation of Leishmania infantum Ribose 5-Phosphate Isomerase as a Drug Target.Antimicrobial agents and chemotherapy · 2021Article
- Dual and selective inhibitors of pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) fromJournal of enzyme inhibition and medicinal chemistry · 2019Article
- Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.Cell chemical biology · 2019Article
- Future Prospects in the Treatment of Parasitic Diseases: 2-Amino-1,3,4-Thiadiazoles in Leishmaniasis.Molecules (Basel, Switzerland) · 2019Review
- Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform.SLAS discovery : advancing life sciences R & D · 2019Article
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Authors and funding
39 authors at 10 institutions in 8 countries.
Pasquale LincianoDipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
Alice DawsonBiological Chemistry & Drug Discovery, School of Life Sciences, The Wellcome Trust Building, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Ina PöhnerMolecular and Cellular Modeling Group and Scientific Databases and Visualization (SDBV) Group, Heidelberg Institute for Theoretical Studies, Schloss-Wolfsbrunnenweg 35, D-69118 Heidelberg, Germany.
David M CostaInstituto de Investigação e Inovação em Saúde, Instituto de Biologia Molecular e Celular, and Departamento de Ciências Biológicas, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
Monica S SáInstituto de Investigação e Inovação em Saúde, Instituto de Biologia Molecular e Celular, and Departamento de Ciências Biológicas, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
Anabela Cordeiro-da-SilvaInstituto de Investigação e Inovação em Saúde, Instituto de Biologia Molecular e Celular, and Departamento de Ciências Biológicas, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
Rosaria LucianiDipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
Sheraz GulFraunhofer-IME SP, Schnackenburgallee 114, D-22525 Hamburg, Germany.
Gesa WittFraunhofer-IME SP, Schnackenburgallee 114, D-22525 Hamburg, Germany.
Bernhard EllingerFraunhofer-IME SP, Schnackenburgallee 114, D-22525 Hamburg, Germany.
Maria KuzikovFraunhofer-IME SP, Schnackenburgallee 114, D-22525 Hamburg, Germany.
Philip GribbonFraunhofer-IME SP, Schnackenburgallee 114, D-22525 Hamburg, Germany.
Jeanette ReinshagenFraunhofer-IME SP, Schnackenburgallee 114, D-22525 Hamburg, Germany.
Markus WolfFraunhofer-IME SP, Schnackenburgallee 114, D-22525 Hamburg, Germany.
Birte BehrensFraunhofer-IME SP, Schnackenburgallee 114, D-22525 Hamburg, Germany.
Véronique HannaertResearch Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium.
Paul A M MichelsResearch Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium.
Erika NeriniDipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
Cecilia PozziUniversity of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Flavio di PisaUniversity of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Giacomo LandiUniversity of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Nuno SantaremInstituto de Investigação e Inovação em Saúde, Instituto de Biologia Molecular e Celular, and Departamento de Ciências Biológicas, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.
Stefania FerrariDipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
Puneet SaxenaDipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
Sandra LazzariDipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
Giuseppe CannazzaDipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
Lucio H Freitas-JuniorLaboratório Nacional de Biociências CNPEM, Centro Nacional de Pesquisa em Energia e Materials, Rua Giuseppe Máximo Scolfaro, 10.000, CEP 13083-970 Campinas/SP, Brasil.
Carolina B MoraesLaboratório Nacional de Biociências CNPEM, Centro Nacional de Pesquisa em Energia e Materials, Rua Giuseppe Máximo Scolfaro, 10.000, CEP 13083-970 Campinas/SP, Brasil.
Bruno S PascoalinoLaboratório Nacional de Biociências CNPEM, Centro Nacional de Pesquisa em Energia e Materials, Rua Giuseppe Máximo Scolfaro, 10.000, CEP 13083-970 Campinas/SP, Brasil.
Laura M AlcântaraLaboratório Nacional de Biociências CNPEM, Centro Nacional de Pesquisa em Energia e Materials, Rua Giuseppe Máximo Scolfaro, 10.000, CEP 13083-970 Campinas/SP, Brasil.
Claudia P BertolaciniLaboratório Nacional de Biociências CNPEM, Centro Nacional de Pesquisa em Energia e Materials, Rua Giuseppe Máximo Scolfaro, 10.000, CEP 13083-970 Campinas/SP, Brasil.
Vanessa FontanaLaboratório Nacional de Biociências CNPEM, Centro Nacional de Pesquisa em Energia e Materials, Rua Giuseppe Máximo Scolfaro, 10.000, CEP 13083-970 Campinas/SP, Brasil.
Ulrike WittigMolecular and Cellular Modeling Group and Scientific Databases and Visualization (SDBV) Group, Heidelberg Institute for Theoretical Studies, Schloss-Wolfsbrunnenweg 35, D-69118 Heidelberg, Germany.
Wolfgang MüllerMolecular and Cellular Modeling Group and Scientific Databases and Visualization (SDBV) Group, Heidelberg Institute for Theoretical Studies, Schloss-Wolfsbrunnenweg 35, D-69118 Heidelberg, Germany.
Rebecca C WadeMolecular and Cellular Modeling Group and Scientific Databases and Visualization (SDBV) Group, Heidelberg Institute for Theoretical Studies, Schloss-Wolfsbrunnenweg 35, D-69118 Heidelberg, Germany.
William N HunterBiological Chemistry & Drug Discovery, School of Life Sciences, The Wellcome Trust Building, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Stefano ManganiUniversity of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Luca CostantinoDipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
Maria P CostiDipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
University of Modena and Reggio Emilia · ITFraunhofer Institute for Molecular Biology and Applied Ecology · DEUniversity of Dundee · GBQuantitative BioSciences · USUniversity of Siena · ITi3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto · PTde Duve Institute · BELaboratório Nacional de Ciência e Tecnologia do Bioetanol · BRHeidelberg Institute for Theoretical Studies · DEUniversidade do Porto · PT
Funding
Wellcome Trust 094090
Abstract
Pteridine reductase-1 (PTR1) is a promising drug target for the treatment of trypanosomiasis. We investigated the potential of a previously identified class of thiadiazole inhibitors of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.