Evidence map›Paper›PMID 28983503›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2017

Alzheimer's disease genetic risk variants beyond

Jesse Mez, Jessica R Marden, Shubhabrata Mukherjee, Stefan Walter, Laura E Gibbons, Alden L Gross, Laura B Zahodne, Paola Gilsanz, Paul Brewster, Kwangsik Nho and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Reserve and Alzheimer's disease genetic risk: Effects on hospitalization and mortality.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019
    Article
  6. Article
  7. Article
  8. Variation in TMEM106B in chronic traumatic encephalopathy.Acta neuropathologica communications · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 2 countries.

Jesse MezAlzheimer's Disease and Chronic Traumatic Encephalopathy Center, Boston University School of Medicine, Boston, MA, USA.
Jessica R MardenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Shubhabrata MukherjeeDepartment of Medicine, University of Washington, Seattle, WA, USA.
Stefan WalterDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Laura E GibbonsDepartment of Medicine, University of Washington, Seattle, WA, USA.
Alden L GrossDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health and Johns Hopkins University Center on Aging and Health, Baltimore, MD, USA.
Laura B ZahodneDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Paola GilsanzDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Paul BrewsterInstitute on Aging & Lifelong Health, University of Victoria, Victoria, BC, Canada.
Kwangsik NhoCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, WA, USA.
Eric B LarsonKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
M Maria GlymourDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
University of California, San Francisco · USUniversity of Washington · USBoston University · USIndiana University School of MedicineJohns Hopkins University · USKaiser Permanente Washington Health Research Institute · USStanley Foundation · USUniversity of Michigan–Ann Arbor · USUniversity of Victoria · CA

Funding

THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI JAYADEY, SUMAN · 1985 to 2019
$57.2M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
Neuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1M
Training Program in Psychiatric Genetics and Translational ResearchT32MH017119 · NIMH · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KARESTAN C KOENEN, Jukka-Pekka Onnela · 1985 to 2026
$8.9M
Integrating Neuroimaging, Multi-omics, and Clinical Data in Complex DiseaseR01LM012535 · NLM · INDIANA UNIVERSITY INDIANAPOLIS · PI NHO, KWANGSIK TIMOTHY · 2017 to 2021
$1.7M
Integration of Bio-, Medical, and Imaging Informatics for Complex DiseasesR00LM011384 · NLM · INDIANA UNIVERSITY INDIANAPOLIS · PI NHO, KWANGSIK TIMOTHY · 2013 to 2015
$647k
Genetic and Neuropsychological Heterogeneity in Alzheimer's DiseaseK23AG046377 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MEZ, JESSE BENJAMIN · 2014 to 2018
$639k
Conference on Advanced Psychometric Methods in Cognitive Aging ResearchR13AG030995 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MUNGAS, DAN M. · 2008 to 2022
$620k
Psychosocial protective factors in cognitive and brain agingK99AG047963 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZAHODNE, LAURA B · 2014 to 2015
$264k
Neurogenesis in Adult Brain: Gene Networks and Alzheimer’s DiseaseR03AG054936 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI NHO, KWANGSIK TIMOTHY · 2017 to 2018
$145k
Short and long term depressive symptoms and arrhythmic pathways to strokeF31HL112613 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI GILSANZ, PAOLA · 2012 to 2013
$67k
NHLBI NIH HHS F31 HL112613NIA NIH HHS K23 AG046377NIA NIH HHS K99 AG047963NIA NIH HHS P30 AG013846NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005146NIA NIH HHS R13 AG030995NIA NIH HHS U01 AG006781NIMH NIH HHS T32 MH017119NLM NIH HHS R00 LM011384NLM NIH HHS R01 LM012535
6 · The paper itself

Abstract

introductionWe hypothesized that, like apolipoprotein E (

methodsWe used a weighted genetic risk score (GRS) from 21 non-

resultsHigher GRS predicted mortality (hazard ratio = 1.05; 95% confidence interval: 1.00-1.10, DISCUSSION: Non-

Indexed as

Adult Changes in Thought (ACT)Alzheimer's diseaseAPOECohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)Collider stratification biasGenetic risk scoreGenome-wide association study (GWAS)Health and Retirement Study (HRS)LongevityMortalitySelection biasSurvival analysisSurvivor bias

Identifiers

PMID28983503
PMCPMC5604953
OpenAlexW2748982016

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.