ArticleOptica2016
Fractal propagation method enables realistic optical microscopy simulations in biological tissues.
Article in Optica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 55 citations in OpenAlex.
- Identification of cancerous tissues based on residual neural network.Scientific reports · 2025Article
- Persistent homology-based optical properties of microscopic turbid media for realistic light propagation analysis.Biomedical optics express · 2025Article
- Ultralow radiant exposure of a short-pulsed laser to disrupt melanosomes with localized thermal damage through a turbid medium.Scientific reports · 2024Article
- Implantable photonic neural probes with out-of-plane focusing grating emitters.Scientific reports · 2024Article
- Fractal-based aberration-corrected full-field OCT.Biomedical optics express · 2023Article
- Modeling nonlinear optical microscopy in scattering media, part I. Propagation from lens to focal volume: tutorial.Journal of the Optical Society of America. A, Optics, image science, and vision · 2023Article
- Holistic Monte-Carlo optical modelling of biological imaging.Scientific reports · 2019Article
- Multidirectional digital scanned light-sheet microscopy enables uniform fluorescence excitation and contrast-enhanced imaging.Scientific reports · 2018Article
- Biobeam-Multiplexed wave-optical simulations of light-sheet microscopy.PLoS computational biology · 2018Article
- Bessel-beam illumination in dual-axis confocal microscopy mitigates resolution degradation caused by refractive heterogeneities.Journal of biophotonics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Current simulation methods for light transport in biological media have limited efficiency and realism when applied to three-dimensional microscopic light transport in biological tissues with refractive heterogeneities. We describe here a technique which combines a beam propagation method valid for modeling light transport in media with weak variations in refractive index, with a fractal model of refractive index turbulence. In contrast to standard simulation methods, this fractal propagation method (FPM) is able to accurately and efficiently simulate the diffraction effects of focused beams, as well as the microscopic heterogeneities present in tissue that result in scattering, refractive beam steering, and the aberration of beam foci. We validate the technique and the relationship between the FPM model parameters and conventional optical parameters used to describe tissues, and also demonstrate the method's flexibility and robustness by examining the steering and distortion of Gaussian and Bessel beams in tissue with comparison to experimental data. We show that the FPM has utility for the accurate investigation and optimization of optical microscopy methods such as light-sheet, confocal, and nonlinear microscopy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.