Evidence map›Paper›PMID 28983300›Full record

ReviewFrontiers in immunology2017

Human Tregs Made Antigen Specific by Gene Modification: The Power to Treat Autoimmunity and Antidrug Antibodies with Precision.

Patrick R Adair, Yong Chan Kim, Ai-Hong Zhang, Jeongheon Yoon, David W Scott

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Epitope-based precision immunotherapy of Type 1 diabetes.Human vaccines & immunotherapeutics · 2023
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Induction of CD4Biology · 2020
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Regulatory T cells in the treatment of disease.Nature reviews. Drug discovery · 2018
    Review
  20. Engineering therapeutic T cells to suppress alloimmune responses using TCRs, CARs, or BARs.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Patrick R AdairDepartment of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Yong Chan KimDepartment of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Ai-Hong ZhangDepartment of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Jeongheon YoonDepartment of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
David W ScottDepartment of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

Funding

Induction of Tolerance to FVIII in HemophiliaR01HL126727 · NHLBI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI PRATT, KATHLEEN PALMER, SCOTT, DAVID WILLIAM · 2015 to 2022
$3.2M
Engineered CARs Targeting FVIII-specific T and B CellsR21HL127495 · NHLBI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI SCOTT, DAVID WILLIAM · 2016 to 2017
$424k
NHLBI NIH HHS R01 HL126727NHLBI NIH HHS R21 HL127495
6 · The paper itself

Abstract

Human regulatory CD4

Indexed as

antigen-specific TregsB cell antibody receptorschimeric antigen receptorexperimental autoimmune encephalomyelitishemophilia Ahuman regulatory CD4+ T cellsTregs

Identifiers

PMID28983300
PMCPMC5613123

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.