ReviewFrontiers in human neuroscience2017
Role of the Contralesional vs. Ipsilesional Hemisphere in Stroke Recovery.
Review in Frontiers in human neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
112 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- EEG biomarkers for assessment, prognosis, and monitoring of natural upper limb recovery after stroke: a systematic review.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Pooled it
- Systematic review: Resting state functional MRI as a biomarker for non-invasive brain stimulation in upper limb recovery post-stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Non-invasive brain stimulation contributing to postural control with and without stroke: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- A systematic review of alterations in brain activation and intensity following stroke: implications for integration and functional outcomes.Frontiers in neurology · 2025Pooled it
- Enhancing functional motor outcomes in chronic stroke: A systematic review of the growing role of non-invasive brain stimulation.PloS one · 2025Pooled it
- A systematic review of alterations in sensorimotor networks following stroke: implications for integration and functional outcomes across recovery stages.Frontiers in neurology · 2025Pooled it
- Brain activity during real-time walking and with walking interventions after stroke: a systematic review.Journal of neuroengineering and rehabilitation · 2021Pooled it
- Cortical Thickness of Brain Areas Beyond Stroke Lesions and Sensory-Motor Recovery: A Systematic Review.Frontiers in neuroscience · 2021Pooled it
- Guided corticomuscular neuroplasticity for restoration of wrist-hand function post-stroke.Journal of neuroengineering and rehabilitation · 2026Trial
- Clinical and neurophysiological effects of manual acupuncture for upper-limb motor dysfunction after ischemic stroke: a three-arm randomized controlled trial.Frontiers in neurology · 2026Trial
- Efficacy of brain-computer interface training with motor imagery-contingent feedback in improving upper limb function and neuroplasticity among persons with chronic stroke: a double-blinded, parallel-group, randomized controlled trial.Journal of neuroengineering and rehabilitation · 2025Trial
- Effects of Transcranial Direct Current Stimulation Followed by Treadmill Training on Dual-Task Walking and Cortical Activity in Chronic Stroke: A Double-Blinded Randomized Controlled Trial.Journal of rehabilitation medicine · 2023Trial
- Low-Frequency rTMS over Contralesional M1 Increases Ipsilesional Cortical Excitability and Motor Function with Decreased Interhemispheric Asymmetry in Subacute Stroke: A Randomized Controlled Study.Neural plasticity · 2022Trial
- Evidence of neuroplasticity with robotic hand exoskeleton for post-stroke rehabilitation: a randomized controlled trial.Journal of neuroengineering and rehabilitation · 2021Trial
- Feasibility and potential effects of using the electro-dress Mollii on spasticity and functioning in chronic stroke.Journal of neuroengineering and rehabilitation · 2020Trial
- Intensive virtual reality and robotic based upper limb training compared to usual care, and associated cortical reorganization, in the acute and early sub-acute periods post-stroke: a feasibility study.Journal of neuroengineering and rehabilitation · 2019Trial
- Peripheral nerve pathway reconnections promote the reorganization of central motor representations.Science China. Life sciences · 2026Article
- Enriched Environment Enhances Motor Function in Mice With Cerebral Infarction by Promoting mTOR-Dependent Autophagy in the Contralateral Dentate Nucleus.The Kaohsiung journal of medical sciences · 2026Article
- Enhanced hippocampal-cortical functional connectivity following post-stroke cognitive impairment: a resting-state functional magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2026Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Following a stroke, the resulting lesion creates contralateral motor impairment and an interhemispheric imbalance involving hyperexcitability of the contralesional hemisphere. Neuronal reorganization may occur on both the ipsilesional and contralesional hemispheres during recovery to regain motor functionality and therefore bilateral activation for the hemiparetic side is often observed. Although ipsilesional hemispheric reorganization is traditionally thought to be most important for successful recovery, definitive conclusions into the role and importance of the contralesional motor cortex remain under debate. Through examining recent research in functional neuroimaging investigating motor cortex changes post-stroke, as well as brain-computer interface (BCI) and transcranial magnetic stimulation (TMS) therapies, this review attempts to clarify the contributions of each hemisphere toward recovery. Several functional magnetic resonance imaging studies suggest that continuation of contralesional hemisphere hyperexcitability correlates with lesser recovery, however a subset of well-recovered patients demonstrate contralesional motor activity and show decreased functional capability when the contralesional hemisphere is inhibited. BCI therapy may beneficially activate either the contralesional or ipsilesional hemisphere, depending on the study design, for chronic stroke patients who are otherwise at a functional plateau. Repetitive TMS used to excite the ipsilesional motor cortex or inhibit the contralesional hemisphere has shown promise in enhancing stroke patients' recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.