Evidence map›Paper›PMID 28983236›Full record

ReviewFrontiers in neuroscience2017

Development of a Clinical Pathway and Technical Aspects of Upper Airway Stimulation Therapy for Obstructive Sleep Apnea.

Olivier M Vanderveken, Jolien Beyers, Sara Op de Beeck, Marijke Dieltjens, Marc Willemen, Johan A Verbraecken, Wilfried A De Backer, Paul H Van de Heyning

3 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06372847 narecruitingnot on this mapstarted 2025, after this paper: background citation

Assessment of the Effect of Hypoglossal Nerve Stimulation Therapy on the Site of Collapse During DISE

TypeinterventionalSponsorUniversity Hospital, AntwerpRan2025 to 2028Enrolled58ConditionsObstructive Sleep ApneaArmsHypoglossal nerve stimulation implant, Polysomnography, Drug-induced sleep endoscopy (DISE)
NCT07074288 narecruitingnot on this mapstarted 2025, after this paper: background citation

Obstructive Sleep Apnea Non-PAP Outcomes and Viable Alternatives (OSANOVA): Comparison of Mandibular Advancement Device and Hypoglossal Nerve Stimulation Outcomes

TypeinterventionalSponsorWashington University School of MedicineRan2025 to 2027Enrolled60ConditionsObstructive Sleep ApneaArmsMAD, HGNS
NCT07337239 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Assessment of the Effect of Hypoglossal Nerve Stimulation Therapy on Upper Airway Collapsibility During Drug-induced Sleep Endoscopy

TypeinterventionalSponsorUniversity Hospital, AntwerpRan2026 to 2027Enrolled21ConditionsObstructive Sleep ApneaArmsAdditional measurements during clinical standard follow-up drug-induced sleep endoscopy (DISE)
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Surgical failure guided by DISE in patients with obstructive sleep apnea: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023
    Review
  12. Article
  13. Review
  14. Non-CPAP therapy for obstructive sleep apnoea.Breathe (Sheffield, England) · 2022
    Review
  15. Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea in Spain: Implementation Strategy and Early Results in a Tertiary Care Center.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
  16. Observational
  17. Article
  18. Long-term changes of stimulation intensities in hypoglossal nerve stimulation.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Olivier M VandervekenFaculty of Medicine and Health Sciences, University of AntwerpAntwerp, Belgium.
Jolien BeyersFaculty of Medicine and Health Sciences, University of AntwerpAntwerp, Belgium.
Sara Op de BeeckFaculty of Medicine and Health Sciences, University of AntwerpAntwerp, Belgium.
Marijke DieltjensFaculty of Medicine and Health Sciences, University of AntwerpAntwerp, Belgium.
Marc WillemenMultidisciplinary Sleep Disorders Center, Antwerp University HospitalAntwerp, Belgium.
Johan A VerbraeckenMultidisciplinary Sleep Disorders Center, Antwerp University HospitalAntwerp, Belgium.
Wilfried A De BackerMultidisciplinary Sleep Disorders Center, Antwerp University HospitalAntwerp, Belgium.
Paul H Van de HeyningFaculty of Medicine and Health Sciences, University of AntwerpAntwerp, Belgium.
Antwerp University Hospital · BEUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) is a common disease with high morbidity and related mortality. Narrowing and collapse of the pharyngeal airway during sleep characterize the disease, resulting in a decrease (hypopnea) or a complete cessation (apnea) of oronasal airflow. Upper airway stimulation (UAS), using electrical neurostimulation of the hypoglossal nerve (n. XII) synchronized with ventilation, is a novel, evolving treatment option. UAS was found to be an effective treatment in CPAP-intolerant patients. The treatment success is partly due to the strict selection of the patients, based on previous findings. Furthermore, post-operative follow-up is needed in order to maintain or improve treatment outcome. Therefore, a clinical pathway, which provides structure and standardization, is crucial. In this paper, the aim is to discuss the technical aspects of UAS therapy and to describe a clinical pathway to organize the care process of UAS for OSA in a structured and standardized way.

Indexed as

care pathwayscomplete concentric collapsedrug-induced sleep endoscopyhypoglossal nerve stimulationneurostimulationpathophysiologysleep-disordered breathing

Identifiers

PMID28983236
PMCPMC5613133
OpenAlexW2758752375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.