Evidence map›Paper›PMID 28983067›Full record

ArticleG3 (Bethesda, Md.)2017

Increased LOH due to Defective Sister Chromatid Cohesion Is due Primarily to Chromosomal Aneuploidy and not Recombination.

Dror Sagi, Evgeniya Marcos-Hadad, Vinay K Bari, Michael A Resnick, Shay Covo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis.Cellular and molecular life sciences : CMLS · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Dror SagiDepartment of Plant Pathology and Microbiology, Hebrew University, Rehovot 76100, Israel.
Evgeniya Marcos-HadadDepartment of Plant Pathology and Microbiology, Hebrew University, Rehovot 76100, Israel.
Vinay K BariDepartment of Plant Pathology and Microbiology, Hebrew University, Rehovot 76100, Israel.
Michael A ResnickChromosome Stability Group, Laboratory or Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709.
Shay CovoDepartment of Plant Pathology and Microbiology, Hebrew University, Rehovot 76100, Israel shay.covo@mail.huji.ac.il.
Hebrew University of Jerusalem · ILNational Institute of Environmental Health Sciences · US

Funding

Double Strand Break Repair And RecombinationZIAES021016 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MENENDEZ RENDON, DANIEL · 2009 to 2018
$5.6M
MOLECULAR MECHANISMS OF DNA REPAIR AND RECOMBINATION IN YEASTZ01ES065073 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RESNICK, MICHAEL A · 1991 to 2008
$2.8M
Intramural NIH HHS Z01 ES065073
6 · The paper itself

Abstract

Loss of heterozygosity (LOH) is an important factor in cancer, pathogenic fungi, and adaptation to changing environments. The sister chromatid cohesion process (SCC) suppresses aneuploidy and therefore whole chromosome LOH. SCC is also important to channel recombinational repair to sister chromatids, thereby preventing LOH mediated by allelic recombination. There is, however, insufficient information about the relative roles that the SCC pathway plays in the different modes of LOH. Here, we found that the cohesin mutation

Indexed as

AneuploidyLoss of HeterozygosityCell Cycle ProteinsChromatidsChromosomal Proteins, Non-HistoneRad51 RecombinaseRecombination, GeneticSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCell Cycle ProteinsChromosomal Proteins, Non-HistoneMCD1 protein, S cerevisiaeRAD51 protein, S cerevisiaeRad51 RecombinaseSaccharomyces cerevisiae Proteins

Identifiers

PMID28983067
PMCPMC5633381
OpenAlexW2762604858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.