Evidence map›Paper›PMID 28983058›Full record

ArticleHaematologica2017

Red cell alloimmunization is associated with development of autoantibodies and increased red cell transfusion requirements in myelodysplastic syndrome.

Deepak Singhal, Monika M Kutyna, Rakchha Chhetri, Li Yan A Wee, Sophia Hague, Lakshmi Nath, Shriram V Nath, Romi Sinha, Nicholas Wickham, Ian D Lewis and 7 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 58 citations in OpenAlex.

  1. Trial
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  11. Outpatient transfusions for myelodysplastic syndromes.Hematology. American Society of Hematology. Education Program · 2020
    Review
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  17. Challenges in preventing and treating hemolytic complications associated with red blood cell transfusion.Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine · 2019
    Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 1 country.

Deepak SinghalCancer Centre, Royal Adelaide Hospital, Adelaide, Australia.
Monika M KutynaHaematology Department, SA Pathology, Adelaide, Australia.
Rakchha ChhetriHaematology Department, SA Pathology, Adelaide, Australia.
Li Yan A WeeHaematology Department, SA Pathology, Adelaide, Australia.
Sophia HagueTransfusion Medicine, SA Pathology, Adelaide, Australia.
Lakshmi NathHaematology, Clinpath Laboratories, Adelaide, Australia.
Shriram V NathHaematology, Clinpath Laboratories, Adelaide, Australia.
Romi SinhaBlood, Organ and Tissue Programs, Public Health & Clinical Systems, Department of Health, Adelaide, Australia.
Nicholas WickhamAdelaide Cancer Centre, Ashford Specialist Centre, Adelaide, Australia.
Ian D LewisCancer Centre, Royal Adelaide Hospital, Adelaide, Australia.
David M RossCancer Centre, Royal Adelaide Hospital, Adelaide, Australia.
Peter G BardyCancer Centre, Royal Adelaide Hospital, Adelaide, Australia.
Luen Bik ToCancer Centre, Royal Adelaide Hospital, Adelaide, Australia.
John ReynoldsDepartment of Epidemiology and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
Erica M WoodDepartment of Epidemiology and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
David J RoxbyTransfusion Medicine, SA Pathology, Adelaide, Australia.
Devendra K HiwaseCancer Centre, Royal Adelaide Hospital, Adelaide, Australia devendra.hiwase@sa.gov.au.
South Australia Pathology · AUMonash University · AUCentre for Cancer Biology · AUFlinders University · AUGovernment of Western Australia Department of Health · AURoyal Adelaide Hospital · AUSouth Australian Health and Medical Research Institute · AUUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Up to 90% of patients with a myelodysplastic syndrome require red blood cell transfusion; nevertheless, comprehensive data on red cell alloimmunization in such patients are limited. This study evaluates the incidence and clinical impact of red cell alloimmunization in a large cohort of patients with myelodysplastic syndrome registered in the statewide South Australian-MDS registry. The median age of the 817 patients studied was 73 years, and 66% were male. The cumulative incidence of alloimmunization was 11%. Disease-modifying therapy was associated with a lower risk of alloimmunization while alloimmunization was significantly higher in patients with a revised International Prognostic Scoring System classification of Very Low, Low or Intermediate risk compared to those with a High or Very High risk (

Indexed as

Erythrocyte TransfusionAgedAustraliaAutoantibodiesErythrocytesHumansIsoantibodiesMaleMyelodysplastic SyndromesAutoantibodiesIsoantibodies

Identifiers

PMID28983058
PMCPMC5709101
OpenAlexW2763859108

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.