Evidence map›Paper›PMID 28982982›Full record

ArticleThe Journal of biological chemistry2017

Permeant-specific gating of connexin 30 hemichannels.

Brian Skriver Nielsen, Jette Skov Alstrom, Bruce J Nicholson, Morten Schak Nielsen, Nanna MacAulay

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Model-based evaluation of connexin hemichannel permeability.Computational and structural biotechnology journal · 2025
    Article
  2. Article
  3. Large-pore connexin hemichannels function like molecule transporters independent of ion conduction.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Acute activation of hemichannels by ethanol leads to CaFrontiers in cell and developmental biology · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Connexins in Astrocyte Migration.Frontiers in pharmacology · 2019
    Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Brian Skriver NielsenCenter for Neuroscience, 2200 Copenhagen N, Denmark.
Jette Skov AlstromCenter for Neuroscience, 2200 Copenhagen N, Denmark.
Bruce J NicholsonDepartment of Biochemistry, School of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229.
Morten Schak NielsenDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
Nanna MacAulayCenter for Neuroscience, 2200 Copenhagen N, Denmark. Electronic address: macaulay@sund.ku.dk.
The University of Texas Health Science Center at San Antonio · USUniversity of Copenhagen · DK

Funding

SELECTIVE PERMEABILITY &PORE STRUCTURE OF GAP JUNCTIONR01GM055437 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI NICHOLSON, BRUCE J · 1997 to 2009
$2.6M
NIGMS NIH HHS R01 GM055437
6 · The paper itself

Abstract

Gap junctions confer interconnectivity of the cytoplasm in neighboring cells via docking of two connexons expressed in each of the adjacent membranes. Undocked connexons, referred to as hemichannels, may open and connect the cytoplasm with the extracellular fluid. The hemichannel configuration of connexins (Cxs) displays isoform-specific permeability profiles that are not directly determined by the size and charge of the permeant. To further explore Ca

Indexed as

Ion Channel GatingAmino Acid SubstitutionAnimalsCalcium ChannelsConnexin 30EthidiumGap JunctionsHumansIonsPermeabilityXenopus laevisCalcium ChannelsConnexin 30EthidiumIonsATPconnexinconnexon (hemichannel)fluorescencegatingion channelpermeability

Identifiers

PMID28982982
PMCPMC5723989
OpenAlexW2763529605

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.