Evidence map›Paper›PMID 28982975›Full record

ArticleThe Journal of biological chemistry2017

The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3.

Salome Boroda, Sankeerth Takkellapati, Robert T Lawrence, Samuel W Entwisle, Jennifer M Pearson, Mitchell E Granade, Garrett R Mullins, James M Eaton, Judit Villén, Thurl E Harris

Open access · hybridAbstract readComparative Study
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Architecture and function of yeast phosphatidate phosphatase Pah1 domains/regions.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Role of lipins in cardiovascular diseases.Lipids in health and disease · 2023
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. A review of phosphatidate phosphatase assays.Journal of lipid research · 2020
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Salome BorodaFrom the Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 and.
Sankeerth TakkellapatiFrom the Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 and.
Robert T Lawrencethe Department of Genome Sciences, University of Washington, Seattle, Washington 98195.
Samuel W Entwislethe Department of Genome Sciences, University of Washington, Seattle, Washington 98195.
Jennifer M PearsonFrom the Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 and.
Mitchell E GranadeFrom the Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 and.
Garrett R MullinsFrom the Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 and.
James M EatonFrom the Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 and.
Judit Villénthe Department of Genome Sciences, University of Washington, Seattle, Washington 98195.
Thurl E HarrisFrom the Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 and teh3c@virginia.edu.
University of Virginia · USUniversity of Washington · US

Funding

TRAINING IN THE PHARMACOLOGICAL SCIENCEST32GM007055 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LYNCH, KEVIN R. · 1985 to 2022
$7.2M
Towards a comprehensive roadmap of cellular signaling.R35GM119536 · NIGMS · UNIVERSITY OF WASHINGTON · PI VILLEN, JUDIT · 2016 to 2020
$2.2M
Role of Oxidized neutral lipids in adipocyte functionR01DK101946 · NIDDK · UNIVERSITY OF VIRGINIA · PI HARRIS, THURL E. · 2014 to 2018
$1.7M
NIDDK NIH HHS R01 DK101946NIGMS NIH HHS R35 GM119536NIGMS NIH HHS T32 GM007055
6 · The paper itself

Abstract

Lipins 1, 2, and 3 are Mg

Indexed as

Protein Processing, Post-Translational3T3-L1 CellsAmino Acid SequenceAmino Acid SubstitutionAnimalsBinding SitesConserved SequenceHeLa CellsHumansKineticsLiposomesMiceMicellesMutationNuclear ProteinsPhosphatidate Phosphataselipin 3 protein, mouseLiposomesLpin1 protein, mouseMicellesNuclear ProteinsPhosphatidate PhosphatasePhosphatidic AcidsRecombinant Fusion Proteinsdi-anioniclipinlpin1lpin3mammalian target of rapamycin (mTOR)phosphatasephosphatidic acidphosphatidylethanolaminephosphorylation

Identifiers

PMID28982975
PMCPMC5733587
OpenAlexW2763669665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.