ArticleScience (New York, N.Y.)2017
Calibrated mitotic oscillator drives motile ciliogenesis.
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Crashing by design: Utilizing DNA damage for MCC differentiation.Trends in cell biology · 2026Article
- The cell cycle variant in multiciliated cells incorporates 2 centriole biogenesis cycles.bioRxiv : the preprint server for biology · 2026Article
- McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation.EMBO reports · 2026Article
- Repurposing Cell Cycle Oscillators for Multiciliated Cell Differentiation.Advances in experimental medicine and biology · 2026Review
- Coupling and decoupling of the cell cycle from cell differentiation in development.Development (Cambridge, England) · 2025Review
- Loss of a primary cilia protein ARL13B promotes TGFβ-1 induced EMT of RPE in proliferative vitreoretinopathy via increasing Smad3 expression.Frontiers in cell and developmental biology · 2025Article
- Article
- Positioning centrioles and centrosomes.The Journal of cell biology · 2024Review
- Formation and function of multiciliated cells.The Journal of cell biology · 2024Review
- Live-Imaging Centriole Amplification in Mouse Brain Multiciliated Cells.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- The histone H4K20 methyltransferase SUV4-20H1/KMT5B is required for multiciliated cell differentiation in Xenopus.Life science alliance · 2023Article
- GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program.Cell death & disease · 2023Article
- PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells.eLife · 2022Article
- Development of a multiciliated cell.Current opinion in cell biology · 2022Review
- Article
- Emi2 enables centriole amplification during multiciliated cell differentiation.Science advances · 2022Article
- A PSTAIRE-type cyclin-dependent kinase controls light responses in land plants.Science advances · 2022Article
- CEP97 phosphorylation by Dyrk1a is critical for centriole separation during multiciliogenesis.The Journal of cell biology · 2022Article
- Experimental and Natural Induction ofFrontiers in cell and developmental biology · 2022Review
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Cell division and differentiation depend on massive and rapid organelle remodeling. The mitotic oscillator, centered on the cyclin-dependent kinase 1-anaphase-promoting complex/cyclosome (CDK1-APC/C) axis, spatiotemporally coordinates this reorganization in dividing cells. Here we discovered that nondividing cells could also implement this mitotic clocklike regulatory circuit to orchestrate subcellular reorganization associated with differentiation. We probed centriole amplification in differentiating mouse-brain multiciliated cells. These postmitotic progenitors fine-tuned mitotic oscillator activity to drive the orderly progression of centriole production, maturation, and motile ciliation while avoiding the mitosis commitment threshold. Insufficient CDK1 activity hindered differentiation, whereas excessive activity accelerated differentiation yet drove postmitotic progenitors into mitosis. Thus, postmitotic cells can redeploy and calibrate the mitotic oscillator to uncouple cytoplasmic from nuclear dynamics for organelle remodeling associated with differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.