SynthesisAJNR. American journal of neuroradiology2017
Treatment of Middle Cerebral Artery Aneurysms with Flow-Diverter Stents: A Systematic Review and Meta-Analysis.
Synthesis in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 8 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Untangling the debate: a meta-analysis comparing clipping versus coiling in ruptured middle cerebral artery aneurysms.Neurosurgical review · 2026Pooled it
- Efficacy and safety of flow diverters for the treatment of intracranial aneurysms: a systematic review and meta-analysis.Frontiers in surgery · 2026Pooled it
- Efficacy and safety of low profile stents in Y-stent assisted coil embolization of wide-necked bifurcation aneurysms: a systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- Flow-Diversion Treatment for Unruptured Nonsaccular Intracranial Aneurysms of the Posterior and Distal Anterior Circulation: A Meta-Analysis.AJNR. American journal of neuroradiology · 2020Pooled it
- Treatment of Unruptured Distal Anterior Circulation Aneurysms with Flow-Diverter Stents: A Meta-Analysis.AJNR. American journal of neuroradiology · 2019Pooled it
- Flow-Diversion Treatment of Unruptured Saccular Anterior Communicating Artery Aneurysms: A Systematic Review and Meta-Analysis.AJNR. American journal of neuroradiology · 2019Pooled it
- Y-Stent-Assisted Coiling of Wide-Neck Bifurcation Intracranial Aneurysms: A Meta-Analysis.AJNR. American journal of neuroradiology · 2019Pooled it
- Treatment of Intracranial Aneurysms with Self-Expandable Braided Stents: A Systematic Review and Meta-Analysis.AJNR. American journal of neuroradiology · 2018Pooled it
- Flow Diversion for the Treatment of Distal Circulation Aneurysms: A Randomized Comparison.AJNR. American journal of neuroradiology · 2025Trial
- Early Aneurysm Occlusion Outcomes After Endovascular Treatment: A Descriptive Single-Center Cohort Evaluation.Neurology international · 2026Article
- Safety and efficacy of braided stents as stent monotherapy for the treatment of small intracranial aneurysms.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Introducing the Caliber-Flow Status Scale (CFSS): a novel tool for assessing covered cortical branch status after flow diverter treatment of middle cerebral artery aneurysms.Journal of neurointerventional surgery · 2026Article
- Strategic bypass for future flow diversion: Converting a terminal-type middle cerebral artery aneurysm to a sidewall configuration.Surgical neurology international · 2026Article
- Closer matching between flow diverter diameter and parent artery diameter is associated with improved aneurysm occlusion.Surgical neurology international · 2026Article
- Unruptured middle cerebral artery bifurcation aneurysms: long-term outcomes of endovascular techniques from an 'endovascular-first' policy center.Neuroradiology · 2025Article
- Pipeline embolization device in treating middle cerebral artery aneurysms: a single-center experience in 69 consecutive patients.Neuroradiology · 2025Article
- Flow diverter therapy for mirror-like aneurysms at the middle cerebral artery trifurcation: a case report.Frontiers in surgery · 2025Article
- Tubridge flow diverter for the treatment of dissecting aneurysms in the middle cerebral artery.Frontiers in neurology · 2025Article
- A Case of Flow Diverter Placement for a Recurrent Large Thrombosed Middle Cerebral Artery Aneurysm.Journal of neuroendovascular therapy · 2025Article
- Y Stent-Assisted Coiling Technique for Bifurcation Aneurysms Using Double Neuroform® Stent: a Large Restrospective Series.Clinical neuroradiology · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe safety and efficacy of flow-diversion treatment of MCA aneurysms have not been well-established. PURPOSE: Our aim was to evaluate angiographic and clinical outcomes after flow diversions for MCA aneurysms. DATA SOURCES: A systematic search of PubMed, MEDLINE, and Embase was performed for studies published from 2008 to May 2017. STUDY SELECTION: According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we selected studies with >5 patients describing angiographic and clinical outcomes after flow-diversion treatment of MCA aneurysms. DATA ANALYSIS: Random-effects meta-analysis was used to pool the following outcomes: aneurysm occlusion rate, procedure-related complications, rupture rate of treated aneurysms, and occlusion of the jailed branches. DATA SYNTHESIS: Twelve studies evaluating 244 MCA aneurysms were included in this meta-analysis. Complete/near-complete occlusion was obtained in 78.7% (95% CI, 67.8%-89.7%) of aneurysms. The rupture rate of treated aneurysms during follow-up was 0.4% per aneurysm-year. The rate of treatment-related complications was 20.7% (95% CI, 14%-27.5%), and approximately 10% of complications were permanent. The mortality rate was close to 2%. Nearly 10% (95% CI, 4.7%-15.5%) of jailed arteries were occluded during follow-up, whereas 26% (95% CI, 14.4%-37.6%) had slow flow. Rates of symptoms related to occlusion and slow flow were close to 5%. LIMITATIONS: Small and retrospective series could affect the strength of the reported results.
conclusionsGiven the not negligible rate of treatment-related complications, flow diversion for MCA aneurysms should be considered an alternative treatment when traditional treatment methods are not feasible. However, when performed in this select treatment group, high rates of aneurysm occlusion and protection against re-rupture can be achieved.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.