ArticleThe European respiratory journal2017
Inter-test reproducibility of the lung clearance index measured by multiple breath washout.
Article in The European respiratory journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 72 citations in OpenAlex.
- Pulmonary function in non-hospitalized adults and children after mild COVID-19: a single-centre prospective cohort study.BMC pulmonary medicine · 2025Observational
- Risk of CFTR-related disorders and cystic fibrosis in an Italian cohort of CRMS/CFSPID subjects in preschool and school age.European journal of pediatrics · 2024Observational
- Lung clearance index short-term variability in cystic fibrosis: a pre-post pulmonary exacerbation study.Italian journal of pediatrics · 2024Article
- Longitudinal lung clearance index and association with structural lung damage in children with cystic fibrosis.Thorax · 2023Article
- Effect of Dornase Alfa on the Lung Clearance Index in Children with Cystic Fibrosis: A Lesson from a Case Series.Children (Basel, Switzerland) · 2022Article
- Modulator Therapy in Cystic Fibrosis Patients withJournal of personalized medicine · 2022Article
- Dornase alfa in Cystic Fibrosis: indications, comparative studies and effects on lung clearance index.Italian journal of pediatrics · 2022Review
- Observational
- Result of one-year, prospective follow-up of intensive care unit survivors after SARS-CoV-2 pneumonia.Annals of intensive care · 2022Article
- The Short Term Influence of Chest Physiotherapy on Lung Function Parameters in Children With Cystic Fibrosis and Primary Ciliary Dyskinesia.Frontiers in pediatrics · 2022Article
- Breath detection algorithms affect multiple-breath washout outcomes in pre-school and school age children.PloS one · 2022Article
- Lung Clearance Index in Children with Cystic Fibrosis during Pulmonary Exacerbation.Journal of clinical medicine · 2021Article
- Multiple breath washout: measuring early manifestations of lung pathology.Breathe (Sheffield, England) · 2021Article
- Ex vivo model predicted in vivo efficacy of CFTR modulator therapy in a child with rare genotype.Molecular genetics & genomic medicine · 2021Article
- [Assessment of lung impairment in patients with cystic fibrosis : Novel magnetic resonance imaging methods].Der Radiologe · 2020Review
- Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in.PloS one · 2020Article
- Applications of lung clearance index in monitoring children with cystic fibrosis.World journal of clinical pediatrics · 2019Review
- Does the multiple-breath washout test need to be measured before spirometry?ERJ open research · 2019Article
- Changes in Lung Clearance Index in Preschool-aged Patients with Cystic Fibrosis Treated with Ivacaftor (GOAL): A Clinical Trial.American journal of respiratory and critical care medicine · 2018Article
- Comparison of different analysis algorithms to calculate multiple-breath washout outcomes.ERJ open research · 2018Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
Abstract
The lung clearance index (LCI) has strong intra-test repeatability; however, the inter-test reproducibility of the LCI is poorly defined.The aim of the present study was to define a physiologically meaningful change in LCI in preschool children, which discriminates changes associated with disease progression from biological variability.Repeated LCI measurements from a longitudinal cohort study of children with cystic fibrosis and age-matched controls were collected to define the inter-visit reproducibility of the LCI. Absolute change, the coefficient of variation, Bland-Altman limits of agreement, the coefficient of repeatability, intra-class correlation coefficient, and percentage changes were calculated.LCI measurements (n=505) from 71 healthy and 77 cystic fibrosis participants (aged 2.6-6 years) were analysed. LCI variability was proportional to its magnitude, such that reproducibility defined by absolute changes is biased. A physiologically relevant change for quarterly LCI measurements in health was defined as exceeding ±15%. In clinically stable cystic fibrosis participants, the threshold was higher (±25%); however, for measurements made 24 h apart, the threshold was similar to that observed in health (±17%).A percentage change in LCI greater than ±15% in preschool children can be considered physiologically relevant and greater than the biological variability of the test.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.