Evidence map›Paper›PMID 28982761›Full record

ArticleGenes & development2017

Dense Bicoid hubs accentuate binding along the morphogen gradient.

Mustafa Mir, Armando Reimer, Jenna E Haines, Xiao-Yong Li, Michael Stadler, Hernan Garcia, Michael B Eisen, Xavier Darzacq

Abstract read
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed.

  1. Article
  2. Article
  3. Current Challenges of Transcription Compartmentalization Research.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Breaking anterior-posterior symmetry in the moth flybioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Transcription regulation by biomolecular condensates.Nature reviews. Molecular cell biology · 2025
    Review
  19. Review
  20. Review

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mustafa MirDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California, 94720, USA.
Armando ReimerBiophysics Graduate Group, University of California at Berkeley, Berkeley, California, 94720, USA.
Jenna E HainesDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California, 94720, USA.
Xiao-Yong LiHoward Hughes Medical Institute, University of California at Berkeley, Berkeley, California, 94720, USA.
Michael StadlerDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California, 94720, USA.
Hernan GarciaDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California, 94720, USA.
Michael B EisenDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California, 94720, USA.ORCID 0000-0002-7528-738X
Xavier DarzacqDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California, 94720, USA.ORCID 0000-0003-2537-8395

Funding

Center for 3D Structure and Physics of the GenomeU54DK107980 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DEKKER, JOB, MIRNY, LEONID A · 2015 to 2019
$14.9M
GENOMICST32HG000047 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RASMUS NIELSEN, Daniel Soleyman Rokhsar · 2000 to 2026
$13.5M
MOLECULAR BIOPHYSICS TRAINING GRANTT32GM008295 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HURLEY, JAMES H, WEMMER, DAVID E · 1989 to 2022
$8.1M
Tools For Imaging the Functional Genome in Living Cells and TissuesU01EB021236 · NIBIB · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DARZACQ, XAVIER, SINGER, ROBERT H · 2015 to 2017
$2.5M
NHGRI NIH HHS T32 HG000047NIBIB NIH HHS U01 EB021236NIDDK NIH HHS U54 DK107980NIGMS NIH HHS T32 GM008295
6 · The paper itself

Abstract

Morphogen gradients direct the spatial patterning of developing embryos; however, the mechanisms by which these gradients are interpreted remain elusive. Here we used lattice light-sheet microscopy to perform in vivo single-molecule imaging in early

Indexed as

AnimalsBody PatterningChromatinDrosophila melanogasterDrosophila ProteinsEmbryo, NonmammalianHomeodomain ProteinsNuclear ProteinsProtein BindingSingle Molecule ImagingTrans-ActivatorsTranscription Factorsbcd protein, DrosophilaChromatinDrosophila ProteinsHomeodomain ProteinsNuclear ProteinsTrans-ActivatorsTranscription Factorszld protein, DrosophilaBicoid, ZeldaDrosophilamorphogensingle-molecule fluorescencetranscription factor dynamics

Identifiers

PMID28982761
PMCPMC5666676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.