ArticleAmerican journal of physiology. Lung cellular and molecular physiology2018
Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease.
Open access · bronzeAbstract readEvaluation Study
In one paragraph
Article in American journal of physiology. Lung cellular and molecular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- The Effects of Individual Components of E-Cigarettes on Ion Transport and Airway Surface Liquid Height in Human Bronchial Epithelial Cells.Medicina (Kaunas, Lithuania) · 2025Article
- Unraveling the Mechanism of Action, Binding Sites, and Therapeutic Advances of CFTR Modulators: A Narrative Review.Current issues in molecular biology · 2025Review
- Pulmonary-delivered Anticalin Jagged-1 antagonists reduce experimental airway mucus hyperproduction and obstruction.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Remodeling of Paranasal Sinuses Mucosa Functions in Response to Biofilm-Induced Inflammation.Journal of inflammation research · 2024Review
- Air-Liquid interface cultures to model drug delivery through the mucociliary epithelial barrier.Advanced drug delivery reviews · 2023Review
- The Epithelial Sodium Channel-An Underestimated Drug Target.International journal of molecular sciences · 2023Review
- E-cigarette aerosols of propylene glycol impair BK channel activity and parameters of mucociliary function.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- CC16 drives VLA-2-dependent SPLUNC1 expression.Frontiers in immunology · 2023Article
- Article
- Animal models of cystic fibrosis in the era of highly effective modulator therapies.Current opinion in pharmacology · 2022Review
- Highway to Cell: Selection of the Best Cell-Penetrating Peptide to Internalize the CFTR-Stabilizing iCAL36 Peptide.Pharmaceutics · 2022Article
- A SPLUNC1 Peptidomimetic Inhibits Orai1 and Reduces Inflammation in a Murine Allergic Asthma Model.American journal of respiratory cell and molecular biology · 2022Article
- Renal NOXA1/NOX1 Signaling Regulates Epithelial Sodium Channel and Sodium Retention in Angiotensin II-induced Hypertension.Antioxidants & redox signaling · 2022Article
- Preclinical evaluation of the epithelial sodium channel inhibitor BI 1265162 for treatment of cystic fibrosis.ERJ open research · 2020Article
- Article
- ENaC regulation by phospholipids and DGK explained through mathematical modeling.Scientific reports · 2020Article
- The SPLUNC1-βENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia.Respiratory research · 2020Article
- Cystic Fibrosis: Emergence of Highly Effective Targeted Therapeutics and Potential Clinical Implications.American journal of respiratory and critical care medicine · 2020Review
- Electronic Cigarette Vapor with Nicotine Causes Airway Mucociliary Dysfunction Preferentially via TRPA1 Receptors.American journal of respiratory and critical care medicine · 2019Article
- Thickness of the airway surface liquid layer in the lung is affected in cystic fibrosis by compromised synergistic regulation of the ENaC ion channel.Journal of the Royal Society, Interface · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 1 country.
Shawn T TerryahCystic Fibrosis Center/Marsico Lung Institute, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Robert C FellnerCystic Fibrosis Center/Marsico Lung Institute, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Saira AhmadCystic Fibrosis Center/Marsico Lung Institute, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Patrick J MooreCystic Fibrosis Center/Marsico Lung Institute, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Boris ReidelCystic Fibrosis Center/Marsico Lung Institute, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Juliana I SesmaSpyryx Biosciences, Durham, North Carolina.
Christine S KimCystic Fibrosis Center/Marsico Lung Institute, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Alaina L GarlandCystic Fibrosis Center/Marsico Lung Institute, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
David W ScottSpyryx Biosciences, Durham, North Carolina.
Juan R SabaterDepartment of Research, Mount Sinai Medical Center , Miami Beach, Florida.
Jerome CarpenterCystic Fibrosis Center/Marsico Lung Institute, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Scott H RandellCystic Fibrosis Center/Marsico Lung Institute, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Mehmet KesimerCystic Fibrosis Center/Marsico Lung Institute, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
William M AbrahamDepartment of Research, Mount Sinai Medical Center , Miami Beach, Florida.
William J ArendshorstCell Biology and Physiology, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Robert TarranCystic Fibrosis Center/Marsico Lung Institute, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Lung Institute · USUniversity of North Carolina at Chapel Hill · USMount Sinai Medical Center · USSpyryx Biosciences (United States) · US
Funding
Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Martina Gentzsch · 2004 to 2026
$26.5MPurinergic Control of CFTR-ENaC Interactions in Alveolar EpitheliaP01HL110873 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2012 to 2016
$10.7MThe role of mucin-protein interactions in the innate defense of the lungR01HL103940 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESIMER, MEHMET · 2010 to 2014
$1.8MNHLBI NIH HHS P01 HL110873NHLBI NIH HHS R01 HL103940NIDDK NIH HHS P30 DK065988
Abstract
In cystic fibrosis (CF) lungs, epithelial Na
Indexed as
AnimalsCells, CulturedCystic Fibrosis Transmembrane Conductance RegulatorGlycoproteinsHumansIon TransportLung DiseasesMaleMiceMice, TransgenicPeptidesPhosphoproteinsRatsRats, Sprague-DawleyRespiratory MucosaBPIFA1 protein, humanCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorGlycoproteinsPeptidesPhosphoproteinsS18 peptide
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.