Evidence map›Paper›PMID 28982732›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

Adenosine receptors differentially regulate type 2 cytokine production by IL-33-activated bone marrow cells, ILC2s, and macrophages.

Balázs Csóka, Zoltán H Németh, Claudia U Duerr, Jörg H Fritz, Pál Pacher, György Haskó

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Research square · 2026
    Article
  2. Article
  3. Adenosine-mediated immune responses in inflammatory bowel disease.Frontiers in cell and developmental biology · 2024
    Review
  4. Article
  5. Article
  6. EnterotoxigenicInfection and immunity · 2022
    Article
  7. Article
  8. Review
  9. Article
  10. The trans-omics landscape of COVID-19.Nature communications · 2021
    Article
  11. The adenosine pathway in immuno-oncology.Nature reviews. Clinical oncology · 2020
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Adenosine and the Cardiovascular System.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2019
    Review
  17. Article
  18. Review
  19. Review
  20. Adenosine metabolism, immunity and joint health.Biochemical pharmacology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Balázs CsókaDepartment of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Zoltán H NémethDepartment of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Claudia U DuerrDepartment of Microbiology and Immunology, McGill University Research Center on Complex Traits, McGill University, Montréal, Quebec, Canada.
Jörg H FritzDepartment of Microbiology and Immunology, McGill University Research Center on Complex Traits, McGill University, Montréal, Quebec, Canada.
Pál PacherNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.
György HaskóDepartment of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
McGill University · CAMemorial Medical Center · USNational Institute on Alcohol Abuse and Alcoholism · USRutgers New Jersey Medical SchoolRutgers, The State University of New Jersey · US

Funding

Mechanism of oxidative/nitrosative stress and inflammation-induced tissue injuryZIAAA000375 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI PACHER, PAL · 2009 to 2025
$27.8M
Purinergic signaling in trauma and sepsisR01GM066189 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI HASKO, GEORGE · 2002 to 2020
$4.7M
Purinergic signaling in granuloma-forming Th2 immunityR01DK113790 · NIDDK · RBHS-NEW JERSEY MEDICAL SCHOOL · PI GAUSE, WILLIAM CLARK, HASKO, GEORGE · 2017 to 2020
$1.9M
BD FACSAria II for NJMS Flow Cytometry CoreS10RR027022 · NCRR · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI FITZGERALD-BOCARSLY, PATRICIA · 2011 to 2011
$501k
NCRR NIH HHS S10 RR027022NIDDK NIH HHS R01 DK113790NIGMS NIH HHS R01 GM066189
6 · The paper itself

Abstract

Group 2 innate lymphoid cells (ILC2s) represent a rapid source of type 2 cytokines, such as IL-5 and IL-13, and play an important role in orchestrating type 2 immune response. Adenosine is an endogenous purine nucleoside, a catabolite of ATP that binds and activates ≥1 of 4 transmembrane G protein-coupled cell-surface adenosine receptors (ARs)-A

Indexed as

AnimalsBone Marrow CellsInterleukin-13Interleukin-33Interleukin-5Lymphocyte ActivationMacrophage ActivationMacrophagesMiceMice, KnockoutReceptor, Adenosine A2AReceptor, Adenosine A2BTh2 CellsIl33 protein, mouseInterleukin-13Interleukin-33Interleukin-5Receptor, Adenosine A2AReceptor, Adenosine A2BA2AARA2BARallergic inflammationhelminth infectionILC2s

Identifiers

PMID28982732
PMCPMC5888397
OpenAlexW2761750001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.