Trial reportClinical science (London, England : 1979)2017
Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.
Trial report in Clinical science (London, England : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Similar effects between animal-based and plant-based protein blend as complementary dietary protein on muscle adaptations to resistance training: findings from a randomized clinical trial.Journal of the International Society of Sports Nutrition · 2025Trial
- Trial
- Acute Effects of Cheddar Cheese Consumption on Circulating Amino Acids and Human Skeletal Muscle.Nutrients · 2021Trial
- A Novel Dietary Intervention Reduces Circulatory Branched-Chain Amino Acids by 50%: A Pilot Study of Relevance for Obesity and Diabetes.Nutrients · 2020Trial
- Multifactorial nature of anabolic resistance in ageing skeletal muscle: A systems modelling study.The Journal of physiology · 2026Article
- Leucine Supplementation Counteracts the Atrophic Effects of HDAC4 in Rat Skeletal Muscle Submitted to Hindlimb Immobilization.Muscle & nerve · 2025Article
- Post-prandial tracer studies of protein and amino acid utilisation: what can they tell us about human amino acid and protein requirements?The British journal of nutrition · 2024Review
- Leucine Supplementation Prevents the Development of Skeletal Muscle Dysfunction in a Rat Model of HFpEF.Cells · 2024Article
- Critical variables regulating age-related anabolic responses to protein nutrition in skeletal muscle.Frontiers in nutrition · 2024Review
- Article
- Anabolic Resistance in the Pathogenesis of Sarcopenia in the Elderly: Role of Nutrition and Exercise in Young and Old People.Nutrients · 2023Review
- Amino Acids and the Early Mammalian Embryo: Origin, Fate, Function and Life-Long Legacy.International journal of environmental research and public health · 2021Review
- Principles of stable isotope research - with special reference to protein metabolism.Clinical nutrition open science · 2021Article
- Review
- Review
- Leucine Supplementation DecreasesCells · 2020Article
- Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway.Journal of cachexia, sarcopenia and muscle · 2020Article
- The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?Journal of cachexia, sarcopenia and muscle · 2020Review
- A word of caution against excessive protein intake.Nature reviews. Endocrinology · 2020Review
- Dietary protein and exercise for preservation of lean mass and perspectives on type 2 diabetes prevention.Experimental biology and medicine (Maywood, N.J.) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Leucine modulates muscle protein synthesis (MPS), with potential to facilitate accrual/maintenance of muscle mass. Animal models suggest that leucine boluses shortly after meals may prolong MPS and delay onset of a "muscle-full" state. However, the effects of nutrient "top-ups" in humans, and particularly older adults where deficits exist, have not been explored. We determined the effects of a leucine top-up after essential amino acid (EAA) feeding on anabolic signaling, MPS, and muscle energy metabolism in older men. During
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.