ArticleJournal of cell science2017
Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids.
Article in Journal of cell science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Mitotic shape changes drive spatiotemporally segregated cell-contact rearrangements in a proliferating epithelium.Current biology : CB · 2026Article
- Zebrafish otic vesicle and mouse epididymis as model systems for studying columnar epithelial cell division.Scientific reports · 2026Article
- Zebrafish otic vesicle and mouse epididymis as model systems for studying columnar epithelial cell division.bioRxiv : the preprint server for biology · 2025Article
- Basal Cell-Contact Dynamics Influence Tissue Packing in a Proliferating Mammalian Epithelium.bioRxiv : the preprint server for biology · 2025Article
- Pirin, an Nrf2-Regulated Protein, Is Overexpressed in Human Colorectal Tumors.Antioxidants (Basel, Switzerland) · 2022Article
- Insights Into Mechanisms of Oriented Division From Studies in 3D Cellular Models.Frontiers in cell and developmental biology · 2022Review
- Current knowledge on the multiform reconstitution of intestinal stem cell niche.World journal of stem cells · 2021Review
- Spindle positioning and its impact on vertebrate tissue architecture and cell fate.Nature reviews. Molecular cell biology · 2021Review
- Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury.Neoplasia (New York, N.Y.) · 2021Article
- Capturing Stem Cell Behavior Using Intravital and Live Cell Microscopy.Cold Spring Harbor perspectives in biology · 2020Review
- Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche.Nature communications · 2020Article
- Article
- Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila.American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Homeostasis of renewing tissues requires balanced proliferation, differentiation and movement. This is particularly important in the intestinal epithelium where lineage tracing suggests that stochastic differentiation choices are intricately coupled to the position of a cell relative to a niche. To determine how position is achieved, we followed proliferating cells in intestinal organoids and discovered that the behaviour of mitotic sisters predicted long-term positioning. We found that, normally, 70% of sisters remain neighbours, while 30% lose contact and separate after cytokinesis. These post-mitotic placements predict longer term differences in positions assumed by sisters: adjacent sisters reach similar positions over time; in a pair of separating sisters, one remains close to its birthplace while the other is displaced upward. Computationally modelling crypt dynamics confirmed that post-mitotic separation leads to sisters reaching different compartments. We show that interkinetic nuclear migration, cell size and asymmetric tethering by a process extending from the basal side of cells contribute to separations. These processes are altered in adenomatous polyposis coli (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.