ArticleUltrasound in medicine & biology2017
First-in-Human Study of Acoustic Angiography in the Breast and Peripheral Vasculature.
Article in Ultrasound in medicine & biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Implementation of a Novel 288-Element Dual-Frequency Array for Acoustic Angiography: In Vitro and In Vivo Characterization.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Characterization of an Array-Based Dual-Frequency Transducer for Superharmonic Contrast Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Advances in translational imaging of the microcirculation.Microcirculation (New York, N.Y. : 1994) · 2021Review
- An Improved CMUT Structure Enabling Release and Collapse of the Plate in the Same Tx/Rx Cycle for Dual-Frequency Acoustic Angiography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
- Visualization of Microvascular Angiogenesis Using Dual-Frequency Contrast-Enhanced Acoustic Angiography: A Review.Ultrasound in medicine & biology · 2020Review
- Superharmonic Ultrasound for Motion-Independent Localization Microscopy: Applications to Microvascular Imaging From Low to High Flow Rates.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020Article
- Use of 3-D Contrast-Enhanced Ultrasound to Evaluate Tumor Microvasculature After Nanoparticle-Mediated Modulation.Ultrasound in medicine & biology · 2020Article
- Microvascular Ultrasonic Imaging of Angiogenesis Identifies Tumors in a Murine Spontaneous Breast Cancer Model.International journal of biomedical imaging · 2020Article
- Increasing Doxorubicin Loading in Lipid-Shelled Perfluoropropane NanobubblesFrontiers in pharmacology · 2020Article
- Assessment of the Superharmonic Response of Microbubble Contrast Agents for Acoustic Angiography as a Function of Microbubble Parameters.Ultrasound in medicine & biology · 2019Article
- In Vitro Superharmonic Contrast Imaging Using a Hybrid Dual-Frequency Probe.Ultrasound in medicine & biology · 2019Article
- Ultrasound multiple scattering with microbubbles can differentiate between tumor and healthy tissue in vivo.Physics in medicine and biology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Screening with mammography has been found to increase breast cancer survival rates by about 20%. However, the current system in which mammography is used to direct patients toward biopsy or surgical excision also results in relatively high rates of unnecessary biopsy, as 66.8% of biopsies are benign. A non-ionizing radiation imaging approach with increased specificity might reduce the rate of unnecessary biopsies. Quantifying the vascular characteristics within and surrounding lesions represents one potential target for assessing likelihood of malignancy via imaging. In this clinical note, we describe the translation of a contrast-enhanced ultrasound technique, acoustic angiography, to human imaging. We illustrate the feasibility of this technique with initial studies in imaging the hand, wrist and breast using Definity microbubble contrast agent and a mechanically steered prototype dual-frequency transducer in healthy volunteers. Finally, this approach was used to image pre-biopsy Breast Imaging Reporting and Data System (BI-RADS) 4 and 5 lesions <2 cm in depth in 11 patients. Results indicate that sensitivity and spatial resolution are sufficient to image vessels as small as 0.2 mm in diameter at depths of ~15 mm in the human breast. Challenges observed include motion artifacts, as well as limited depth of field and sensitivity, which could be improved by correction algorithms and improved transducer technologies.
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Registered trials
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