ArticleCancer imaging : the official publication of the International Cancer Imaging Society2017
Lymphomatosis cerebri: a rare variant of primary central nervous system lymphoma and MR imaging features.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Lymphomatosis Cerebri Presenting as Steroid-Refractory Demyelinating Disease: A Diagnostic Challenge.Cureus · 2026Article
- Usefulness and pitfalls of neuroendoscopic tumor biopsy for intracranial malignant lymphoma.Neurosurgical review · 2025Article
- Primary central nervous system lymphoma with diffuse subcortical white matter diffusion restriction.The neuroradiology journal · 2024Article
- Case Report: Diffuse cerebral lymphomatosis with superimposed multifocal primary CNS lymphoma.Frontiers in radiology · 2024Article
- Lymphomatosis Cerebri: A diagnostic dilemma.Annals of neurosciences · 2024Article
- Residual diffusion-weighted imaging hyperintense signal in primary central nervous system lymphoma can predict early recurrence.Journal of neuro-oncology · 2023Article
- A very rare cause of leukoencephalopathy: Lymphomatosis cerebri.Intractable & rare diseases research · 2023Article
- Imaging of Lymphomas Involving the CNS: An Update-Review of the Full Spectrum of Disease with an Emphasis on the World Health Organization Classifications of CNS Tumors 2021 and Hematolymphoid Tumors 2022.AJNR. American journal of neuroradiology · 2023Review
- Neuropathology of Central and Peripheral Nervous System Lymphoma in Dogs and Cats: A Study of 92 Cases and Review of the Literature.Animals : an open access journal from MDPI · 2023Article
- Lymphomatosis cerebri: a rare diffuse leukoencephalopathy you should never miss.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Article
- Intelligent Diagnosis and Analysis of Brain Lymphoma Based on DSC Imaging Features.Computational intelligence and neuroscience · 2022Article
- Primary central nervous system lymphoma initially manifesting as cerebral white matter lesions followed by isolated extracerebral relapse: a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Lymphomatosis cerebri: Multimodality imaging features and misdiagnosis analysis.Oncology letters · 2021Article
- Distribution of Deep Gray Matter Lesions on Magnetic Resonance Imaging in Lymphomatosis Cerebri.Internal medicine (Tokyo, Japan) · 2021Article
- Diagnosis and analysis of primary central nervous system lymphoma based on MRI segmentation algorithm.Pakistan journal of medical sciences · 2021Article
- Case Report: Paraneoplastic Hashimoto's Encephalopathy Associated With Lymphomatosis Cerebri With Periodic Synchronous Discharges Resembling Creutzfeldt-Jakob Disease.Frontiers in neurology · 2021Article
- Diffuse Infiltrative Non-mass-like Brain Parenchymal Lesions on MRI: Differentiating Lymphomatosis Cerebri from its Mimics.Journal of clinical imaging science · 2021Article
- Visual hallucinations as psychiatric onset of a primary central nervous system lymphoma: a case report and a brief review of literature on neoplasm-correlated neuropsychiatric disorders.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Review
- Parkinsonism as a late presentation of lymphomatosis cerebri following high-dose chemotherapy with autologous stem cell transplantation for primary central nervous system lymphoma.Journal of neurology · 2020Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundLymphomatosis cerebri (LC) is a rare variant of primary central nervous system lymphoma (PCNSL), characterized by diffuse infiltration without the formation of a discrete mass. The diagnosis of LC is a challenge because the imaging findings are atypical for lymphoma. The purpose of present study is to investigate MRI characteristics and clinical features of LC and potentially facilitate an early and accurate diagnosis of this often-missed disease.
methodsSeven patients (average 44 years, 19-58 years) with LC proved basing on MRI and histology were retrospectively reviewed the clinical data and cerebral MR imaging findings.
resultsThe common presenting symptoms were cognitive decline, behavioral disturbance, gait disturbance. All patients had both deep and lobar lesion distribution, and two of them had infratentorial involvement. Lack of contrast enhancement and subtle patchy enhanced pattern were observed in two and three patients, respectively. The remaining two patients presented multiple patchy enhancement. Most of the lesions were slightly hyperintense to normal brain on DWI as well as hyperintense on ADC maps. Three patients presented a pattern of marked decrease of NAA/Cr, increase of Cho/Cr, and two of the three cases showed increased Lip/Cr and Lac/Cr on MRS.
conclusionsWe conclude that diffuse bilateral lesions especially in deep and lobar region including white and gray matter, without enhancement or with patchy enhancement, marked decrease of NAA/Cr and increase of Cho/Cr, and increased Lip/Cr and Lac/Cr are suggestive of LC. Prompt recognition of these imaging patterns may lead to early diagnosis of LC and brain biopsy with improved prognosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.