ArticleVeterinary research2017
An avirulent Brachyspira hyodysenteriae strain elicits intestinal IgA and slows down spread of swine dysentery.
Article in Veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Immune Response of Pigs Vaccinated Against Proliferative Enteropathy and Co-Infected withAnimals : an open access journal from MDPI · 2025Article
- SuccessfulPathogens (Basel, Switzerland) · 2025Article
- New insights into swine dysentery: faecal shedding, macro and microscopic lesions and biomarkers in early and acute stages of Brachyspira hyodysenteriae infection.Porcine health management · 2024Article
- Improving the consistency of experimental swine dysentery inoculation strategies.Veterinary research · 2023Article
- Predictive Power of Long-Read Whole-Genome Sequencing for Rapid Diagnostics of Multidrug-Resistant Brachyspira hyodysenteriae Strains.Microbiology spectrum · 2023Article
- In Vitro Screening of Non-Antibiotic Components to Mitigate Intestinal Lesions Caused byAnimals : an open access journal from MDPI · 2022Article
- Experimental natural transmission (seeder pig) models for reproduction of swine dysentery.PloS one · 2022Article
- Article
- Identification and distribution ofVeterinary world · 2021Article
- Differential expression of hemolysin genes in weakly and strongly hemolytic Brachyspira hyodysenteriae strains.BMC veterinary research · 2020Article
- Implementation and evaluation of different eradication strategies forPorcine health management · 2020Article
- An atypical weakly haemolytic strain of Brachyspira hyodysenteriae is avirulent and can be used to protect pigs from developing swine dysentery.Veterinary research · 2019Article
- Weakly haemolytic variants of Brachyspira hyodysenteriae newly emerged in Europe belong to a distinct subclade with unique genetic properties.Veterinary research · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Swine dysentery caused by Brachyspira hyodysenteriae, results in substantial economic losses in swine producing countries worldwide. Although a number of different vaccine approaches have been explored with regard to this disease, they show limitations and none of them have reached the market. We here determine the vaccine potential of a weakly haemolytic B. hyodysenteriae strain. The virulence of this strain was assessed in experimental infection trials and its protection against swine dysentery was quantified in a vaccination-challenge experiment using a seeder infection model. Systemic IgG production and local IgA production were monitored in serum and faeces respectively. Across all trials, pigs that were colonized by virulent, strongly haemolytic B. hyodysenteriae strains consistently developed swine dysentery, in contrast to none of the pigs colonized by the weakly haemolytic B. hyodysenteriae vaccine strain. In the seeder vaccination trial nearly all immunised animals developed swine dysentery on subsequent challenge with a virulent strain, but the speed of spread of swine dysentery and faecal score were significantly reduced in animals immunised with the weakly haemolytic strain compared to sham-immunised animals. The IgA response of immunised animals upon challenge with a virulent B. hyodysenteriae strain significantly correlated to a later onset of disease. The correlation between local IgA production and protection induced by a weakly haemolytic B. hyodysenteriae strain provides leads for future vaccine development against swine dysentery.
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