Evidence map›Paper›PMID 28982374›Full record

ArticleMalaria journal2017

Relationships between infection with Plasmodium falciparum during pregnancy, measures of placental malaria, and adverse birth outcomes.

James Kapisi, Abel Kakuru, Prasanna Jagannathan, Mary K Muhindo, Paul Natureeba, Patricia Awori, Miriam Nakalembe, Richard Ssekitoleko, Peter Olwoch, John Ategeka and 8 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02163447 (Reducing the Burden of Malaria in HIV-uninfected Pregnant Women and Infants), which is not on this map. Cited by 43 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 5 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02163447 phase3completednot on this map

Reducing the Burden of Malaria in HIV-uninfected Pregnant Women and Infants (PROMOTE Birth Cohort 1)

TypeinterventionalSponsorGrant Dorsey, M.D, Ph.D.Ran2014 to 2018Enrolled300ConditionsMalariaArmsMonthly dihydroartemisinin-piperaquine (DP) for adult women during pregnancy, 3 dose dihydroartemisinin-piperaquine (DP) for adult women during pregnancy, 3 dose sulfadoxine-pyrimethamine (SP) for adult women during pregnancy, Monthly dihydroartemisinin-piperaquine (DP) for infants, 3-monthly dihydroartemisinin-piperaquine (DP) for infants
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

James KapisiSchool of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. kapisij@gmail.com.
Abel KakuruInfectious Diseases Research Collaboration, Kampala, Uganda.
Prasanna JagannathanDivision of Infectious Diseases and Geographical Medicine, Stanford University, Stanford, CA, USA.
Mary K MuhindoInfectious Diseases Research Collaboration, Kampala, Uganda.
Paul NatureebaInfectious Diseases Research Collaboration, Kampala, Uganda.
Patricia AworiInfectious Diseases Research Collaboration, Kampala, Uganda.
Miriam NakalembeDepartment of Obstetrics and Gynecology, Makerere University College of Health Sciences, Kampala, Uganda.
Richard SsekitolekoSchool of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Peter OlwochInfectious Diseases Research Collaboration, Kampala, Uganda.
John AtegekaInfectious Diseases Research Collaboration, Kampala, Uganda.
Patience NayebareInfectious Diseases Research Collaboration, Kampala, Uganda.
Tamara D ClarkDepartment of Medicine, University of California, San Francisco, CA, USA.
Gabrielle RizzutoDepartment of Pathology, University of California, San Francisco, CA, USA.
Atis MuehlenbachsDivision of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Diane V HavlirDepartment of Medicine, University of California, San Francisco, CA, USA.
Moses R KamyaSchool of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
Grant DorseyDepartment of Medicine, University of California, San Francisco, CA, USA.
Stephanie L GawDivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA, USA.
Infectious Diseases Research Collaboration · UGUniversity of California, San Francisco · USMakerere University · UGCenters for Disease Control and Prevention · USStanford University · US

Funding

REPRODUCTIVE SCIENTIST TRAINING PROGRAMK12HD000849 · NICHD · WASHINGTON UNIVERSITY · PI Danny J Schust · 1988 to 2026
$33.2M
The immunologic consequences of prenatal exposure to malariaP01HD059454 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAVLIR, DIANE V · 2008 to 2017
$22.6M
Immunologic Consequences of Highly Effective Antimalarial ChemopreventionK23AI100949 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAGANNATHAN, PRASANNA · 2012 to 2016
$657k
6 · The paper itself

Abstract

backgroundMalaria in pregnancy has been associated with maternal morbidity, placental malaria, and adverse birth outcomes. However, data are limited on the relationships between longitudinal measures of malaria during pregnancy, measures of placental malaria, and birth outcomes.

methodsThis is a nested observational study of data from a randomized controlled trial of intermittent preventive therapy during pregnancy among 282 participants with assessment of placental malaria and delivery outcomes. HIV-uninfected pregnant women were enrolled at 12-20 weeks of gestation. Symptomatic malaria during pregnancy was measured using passive surveillance and monthly detection of asymptomatic parasitaemia using loop-mediated isothermal amplification (LAMP). Placental malaria was defined as either the presence of parasites in placental blood by microscopy, detection of parasites in placental blood by LAMP, or histopathologic evidence of parasites or pigment. Adverse birth outcomes assessed included low birth weight (LBW), preterm birth (PTB), and small for gestational age (SGA) infants.

resultsThe 282 women were divided into three groups representing increasing malaria burden during pregnancy. Fifty-two (18.4%) had no episodes of symptomatic malaria or asymptomatic parasitaemia during the pregnancy, 157 (55.7%) had low malaria burden (0-1 episodes of symptomatic malaria and < 50% of samples LAMP+), and 73 (25.9%) had high malaria burden during pregnancy (≥ 2 episodes of symptomatic malaria or ≥ 50% of samples LAMP+). Women with high malaria burden had increased risks of placental malaria by blood microscopy and LAMP [aRR 14.2 (1.80-111.6) and 4.06 (1.73-9.51), respectively], compared to the other two groups combined. Compared with women with no malaria exposure during pregnancy, the risk of placental malaria by histopathology was higher among low and high burden groups [aRR = 3.27 (1.32-8.12) and aRR = 7.07 (2.84-17.6), respectively]. Detection of placental parasites by any method was significantly associated with PTB [aRR 5.64 (1.46-21.8)], and with a trend towards increased risk for LBW and SGA irrespective of the level of malaria burden during pregnancy.

conclusionHigher malaria burden during pregnancy was associated with placental malaria and together with the detection of parasites in the placenta were associated with increased risk for adverse birth outcomes. Trial Registration Current Controlled Trials Identifier NCT02163447.

Indexed as

AdolescentAdultFemaleHumansInfant, Low Birth WeightInfant, NewbornMalaria, FalciparumParasitemiaPlacentaPlasmodium falciparumPregnancyPregnancy Complications, InfectiousPremature BirthPrevalenceUgandaYoung AdultAsymptomatic parasitaemiaBirth outcomesIPTpLAMPLow birth weightMalariaPlacental malariaPregnancyPreterm birthSmall for gestational age

Identifiers

PMID28982374
PMCPMC5629777
OpenAlexW2762042239

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.