ArticleLipids in health and disease2017
Association between single nucleotide polymorphism rs9534275 and the risk of coronary artery disease and ischemic stroke.
Article in Lipids in health and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Genetic variation contributes to gene expression response in ischemic stroke: an eQTL study.Annals of clinical and translational neurology · 2020Article
- Dab2 gene variant is associated with increased coronary artery disease risk in Chinese Han population.Medicine · 2020Article
- BReast CAncer susceptibility gene 2 deficiency exacerbates oxidized LDL-induced DNA damage and endothelial apoptosis.Physiological reports · 2020Article
- Association of theAging · 2020Observational
- Integrated Weighted Gene Co-expression Network Analysis Identified ThatFrontiers in genetics · 2020Article
- A novel circRNA-miRNA-mRNA network identifies circ-YOD1 as a biomarker for coronary artery disease.Scientific reports · 2019Article
- LncRNA SNHG8 is identified as a key regulator of acute myocardial infarction by RNA-seq analysis.Lipids in health and disease · 2019Article
- Association between promoter DNA methylation and gene expression in the pathogenesis of ischemic stroke.Aging · 2019Article
- Association study of two single nucleotide polymorphisms rs10757278 and rs1333049 with atherosclerosis, a case-control study from Iraq.Molecular biology research communications · 2019Article
- Association between the XKR6 rs7819412 SNP and serum lipid levels and the risk of coronary artery disease and ischemic stroke.BMC cardiovascular disorders · 2019Article
- Integrated DNA methylation and gene expression analysis in the pathogenesis of coronary artery disease.Aging · 2019Article
- Circulating miR-3659 may be a potential biomarker of dyslipidemia in patients with obesity.Journal of translational medicine · 2019Article
- A novel lncRNA-miRNA-mRNA triple network identifies lncRNANutrition & metabolism · 2019Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study was to detect the association of single nucleotide polymorphism (SNP) in the breast susceptibility gene 2 (BRCA2) and the risk of coronary artery disease (CAD) and ischemic stroke (IS).
methodsGenotypes of the BRCA2 rs9534275 in 1822 unrelated subjects (CAD, 606; IS, 569; and healthy controls, 647) were determined by the polymerase chain reaction and restriction fragment length polymorphism and then confirmed by direct sequencing.
resultsThe genotypic and allelic frequencies of rs9534275 were significantly different between the CAD, IS patients and controls (P = 0.033 and P = 0.027; respectively). The GG, GT/GG genotypes and G allele were associated with an increased risk of CAD and IS (CAD: P = 0.005 for GG vs. TT, P = 0.004 for GT/GG vs. TT, P = 0.005 for G vs. T; IS: P = 0.003 for GG vs. TT, P = 0.005 for GT/GG vs. TT; P = 0.002 for G vs. T). The GG, GT and GT/GG genotypes in the CAD, but not in healthy controls and IS patients, were associated with an increased serum total cholesterol (TC) and apolipoprotein B (ApoB) concentration.
conclusionsThe present study shows that the G allele carriers of BRCA2 rs9534275 were associated with increased serum TC and ApoB levels in the CAD patients and increased risk of CAD and IS.
trial registrationRetrospectively registered.
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