ArticleSocial cognitive and affective neuroscience2017
Aberrant default-mode network-hippocampus connectivity after sad memory-recall in remitted-depression.
Article in Social cognitive and affective neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
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- Exploring the mediating role of functional connectivity in the association between violence exposure and psychopathology during early adolescence.Brain and cognition · 2026Article
- Evidence of Disrupted Hippocampal Gray- and White-Matter Development in Adolescent Anxiety Disorders, Independent From Early-Life Stress.Hippocampus · 2025Article
- Latent Profile Analysis of Childhood Maltreatment and Neural Markers in Depression.JAMA network open · 2025Article
- Investigating resting-state functional connectivity changes within procedural memory network across neuropsychiatric disorders using fMRI.BMC medical imaging · 2025Article
- Reverse phase protein array-based investigation of mitochondrial genes reveals alteration of glutaminolysis in the parahippocampal cortex of people who died by suicide.Translational psychiatry · 2024Article
- Dynamic network characteristics of adolescents with major depressive disorder: Attention network mediates the association between anhedonia and attentional deficit.Human brain mapping · 2023Article
- Towards assessing subcortical "deep brain" biomarkers of PTSD with functional near-infrared spectroscopy.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Questionnaires based on natural language processing elicit immersive ruminative thinking in ruminators: Evidence from behavioral responses and EEG data.Frontiers in neuroscience · 2023Article
- Altered resting state functional connectivity in youth with congenital heart disease operated during infancy.PloS one · 2022Article
- Neural correlates of repetitive negative thinking: Dimensional evidence across the psychopathological continuum.Frontiers in psychiatry · 2022Article
- Abnormal degree centrality values as a potential imaging biomarker for major depressive disorder: A resting-state functional magnetic resonance imaging study and support vector machine analysis.Frontiers in psychiatry · 2022Article
- Biophysical mechanism of the interaction between default mode network and working memory network.Cognitive neurodynamics · 2021Article
- Abnormal Functional Connectivity of Posterior Cingulate Cortex Correlates With Phonemic Verbal Fluency Deficits in Major Depressive Disorder.Frontiers in neurology · 2021Article
- Blue-Light Therapy Strengthens Resting-State Effective Connectivity within Default-Mode Network after Mild TBI.Journal of central nervous system disease · 2021Article
- Examining Specificity of Neural Correlates of Childhood Psychotic-like Experiences During an Emotional n-Back Task.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Altered Resting-State Functional Connectivity of Multiple Networks and Disrupted Correlation With Executive Function in Major Depressive Disorder.Frontiers in neurology · 2020Article
- Direct Medial Entorhinal Cortex Input to Hippocampal CA3 Is Crucial for eEF2K Inhibitor-Induced Neuronal Oscillations in the Mouse Hippocampus.Frontiers in cellular neuroscience · 2020Article
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6 authors at 3 institutions in 2 countries.
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Abstract
Rumination and cognitive reactivity (dysfunctional cognitions after sad mood-induction) remain high in remitted Major Depressive Disorder (MDD) and can contribute to new episodes. These factors have been linked to increased fMRI resting-state functional-connectivity within the Default-Mode Network (DMN). It remains unclear whether (I) increased DMN-connectivity persists during MDD-remission, and (II) whether sad mood-induction differentially affects DMN-connectivity in remitted-MDD vs controls. Moreover, DMN-connectivity studies in remitted-MDD were previously confounded by antidepressant-use. Sixty-two MDD-patients remitted from ≥2 episodes, psychotropic-medication free, and 41 controls, participated in two 5-min neutral and sad mood-inductions by autobiographical-recall and neutral/sad music, each followed by 8-min resting-state fMRI-scanning. We identified DMN-components using Independent Component Analysis and entered subject- and sessions-specific components into a repeated measures analysis of variance. Connectivity-differences were extracted and correlated with baseline cognitive reactivity and rumination as measures of vulnerability for recurrence. After sad vs neutral mood-induction, controls, but not remitted-MDD, showed an increase in connectivity between the posterior-DMN and a cluster consisting mostly of the hippocampus (P = 0.006). Less posterior-DMN-hippocampal connectivity was associated with higher cognitive reactivity (r = -0.21, P = 0.046) and rumination (r = -0.27, P = 0.017). After recalling sad autobiographical-memories, aberrant posterior-DMN-hippocampal connectivity, associated with cognitive reactivity and rumination, remains a neural vulnerability in MDD-remission.
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