ArticleSchizophrenia bulletin2017
New Research Strategy for Measuring Pre- and Postnatal Metal Dysregulation in Psychotic Disorders.
Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Beyond the Mind-Serum Trace Element Levels in Schizophrenic Patients: A Systematic Review.International journal of molecular sciences · 2020Pooled it
- Zinc in psychosis (Review).Molecular medicine reports · 2025Review
- Associations between prenatal metal and metalloid mixtures in teeth and reductions in childhood lung function.The Science of the total environment · 2024Article
- Postpartum Psychosis: A Review of Risk Factors, Clinical Picture, Management, Prevention, and Psychosocial Determinants.Medical science monitor : international medical journal of experimental and clinical research · 2023Review
- Association Between Measures Derived From Children's Primary Exfoliated Teeth and Psychopathology Symptoms: Results From a Community-Based Study.Frontiers in dental medicine · 2022Article
- Multivariate Patterns of Brain-Behavior-Environment Associations in the Adolescent Brain and Cognitive Development Study.Biological psychiatry · 2021Article
- Early life metal dysregulation in amyotrophic lateral sclerosis.Annals of clinical and translational neurology · 2020Article
- Teeth as Potential New Tools to Measure Early-Life Adversity and Subsequent Mental Health Risk: An Interdisciplinary Review and Conceptual Model.Biological psychiatry · 2020Review
- Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium.Metabolites · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
While previous studies have found evidence for detrimental effects of metals on neurodevelopment, the long-term effects on mental health remain unclear. The objective was to explore the effect of early metal exposure on risk of psychotic disorder and on symptom severity following illness onset. Through the use of validated tooth-biomarkers, we estimated pre- and postnatal exposure levels of essential elements (copper, magnesium, manganese, and zinc) and elements associated with neurotoxicity (lead, arsenic, lithium, and tin). We found consistently higher levels of lithium in patients compared to controls. Higher levels of magnesium and lower levels of zinc were associated with more severe psychopathology over 20 years after metal exposure. The results show promise for the use of teeth biomarkers in examining early environmental risk for psychosis and underscore the relevance of studying metal exposure during critical neurodevelopmental periods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.