ArticleNucleic acids research2017
Subtelomeres constitute a safeguard for gene expression and chromosome homeostasis.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- A CRISPR/Cas9-induced blunt-end telomere system in S. pombe reveals RNase H2-dependent RNA primer removal at the terminal Okazaki fragment of lagging telomeres.Nucleic acids research · 2026Article
- High-resolution genome assembly reveals retrotransposon-mediated centromere dynamics in rye.Genome biology · 2025Article
- Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin.bioRxiv : the preprint server for biology · 2025Article
- RiboCop surveils pre-rRNA processing by Dicer in cellular quiescence.bioRxiv : the preprint server for biology · 2025Article
- Subtelomeric elements provide stability to short telomeres in telomerase-negative cells of the budding yeast Naumovozyma castellii.Current genetics · 2025Article
- Histone deacetylation as a landmark for Sgo2 relocation from centromeres to subtelomeres during interphase.iScience · 2025Article
- Genomic landscape of repetitive DNAs in Neotropical electric fishes.Molecular genetics and genomics : MGG · 2025Article
- Elimination of subtelomeric repeat sequences exerts little effect on telomere essential functions ineLife · 2024Article
- Subtelomeric plasticity contributes to gene family expansion in the human parasitic flatworm Schistosoma mansoni.BMC genomics · 2024Article
- Comparative molecular and conventional cytogenetic analyses of three species of Rhinella (Anura; Bufonidae).PloS one · 2024Article
- Roles of Specialized Chromatin and DNA Structures at Subtelomeres inBiomolecules · 2023Review
- Architecture, Chromatin and Gene Organization ofEpigenomes · 2022Article
- Fission yeast Stn1 maintains stability of repetitive DNA at subtelomere and ribosomal DNA regions.Nucleic acids research · 2021Article
- Subtelomeric Chromatin in the Fission YeastMicroorganisms · 2021Review
- Architecture and evolution of subtelomeres in the unicellular green alga Chlamydomonas reinhardtii.Nucleic acids research · 2021Article
- Idiopathic Infertility as a Feature of Genome Instability.Life (Basel, Switzerland) · 2021Review
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- Repression of a large number of genes requires interplay between homologous recombination and HIRA.Nucleic acids research · 2021Article
- Complete sequences of Schizosaccharomyces pombe subtelomeres reveal multiple patterns of genome variation.Nature communications · 2021Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The subtelomere, a telomere-adjacent chromosomal domain, contains species-specific homologous DNA sequences, in addition to various genes. However, the functions of subtelomeres, particularly subtelomeric homologous (SH) sequences, remain elusive. Here, we report the first comprehensive analyses of the cellular functions of SH sequences in the fission yeast, Schizosaccharomyces pombe. Complete removal of SH sequences from the genome revealed that they are dispensable for mitosis, meiosis and telomere length control. However, when telomeres are lost, SH sequences prevent deleterious inter-chromosomal end fusion by facilitating intra-chromosomal circularization. Surprisingly, SH-deleted cells sometimes survive telomere loss through inter-chromosomal end fusions via homologous loci such as LTRs, accompanied by centromere inactivation of either chromosome. Moreover, SH sequences function as a buffer region against the spreading of subtelomeric heterochromatin into the neighboring gene-rich regions. Furthermore, we found a nucleosome-free region at the subtelomeric border, which may be a second barrier that blocks heterochromatin spreading into the subtelomere-adjacent euchromatin. Thus, our results demonstrate multiple defense functions of subtelomeres in chromosome homeostasis and gene expression.
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