ArticleJournal of experimental botany2017
The Arabidopsis WRINKLED1 transcription factor affects auxin homeostasis in roots.
Article in Journal of experimental botany, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- From wrinkled seeds to plant oil accumulation networks: the legacy of a Plant Physiology classic.Plant physiology · 2026Review
- Genome-Wide Identification ofPlants (Basel, Switzerland) · 2025Article
- Innovative screening for mutants affected in seed oil/protein allocation identifies TRANSPARENT TESTA7 as a regulator of oil accumulation.The Plant journal : for cell and molecular biology · 2025Article
- Genome-wide profiling of soybean WRINKLED1 transcription factor binding sites provides insight into seed storage lipid biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Nitrate Starvation Induces Lateral Root Organogenesis inInternational journal of molecular sciences · 2024Article
- The Roles of GRETCHEN HAGEN3 (GH3)-Dependent Auxin Conjugation in the Regulation of Plant Development and Stress Adaptation.Plants (Basel, Switzerland) · 2023Review
- Control of arbuscule development by a transcriptional negative feedback loop in Medicago.Nature communications · 2023Article
- Recent advances in auxin biosynthesis and homeostasis.3 Biotech · 2023Review
- The molecular mechanism of WRINKLED1 transcription factor regulating oil accumulation in developing seeds of castor bean.Plant diversity · 2023Article
- Improved bioenergy value of residual rice straw by increased lipid levels from upregulation of fatty acid biosynthesis.Biotechnology for biofuels and bioproducts · 2023Article
- Tree peony transcription factor PrWRI1 enhances seed oil accumulation.BMC plant biology · 2023Article
- Bioengineering of Soybean Oil and Its Impact on Agronomic Traits.International journal of molecular sciences · 2023Review
- Transcriptional regulation of oil biosynthesis in seed plants: Current understanding, applications, and perspectives.Plant communications · 2022Review
- Expression of AtWRI1 and AtDGAT1 during soybean embryo development influences oil and carbohydrate metabolism.Plant biotechnology journal · 2022Article
- Potassium Chloroaurate-MediatedNanomaterials (Basel, Switzerland) · 2022Article
- BLISTER promotes seed maturation and fatty acid biosynthesis by interacting with WRINKLED1 to regulate chromatin dynamics in Arabidopsis.The Plant cell · 2022Article
- Cloning and Functional Analysis ofInternational journal of molecular sciences · 2022Article
- Functional Antagonism of WRI1 and TCP20 ModulatesPlants (Basel, Switzerland) · 2022Article
- An expanded role for the transcription factorFrontiers in plant science · 2022Article
- Understanding the Intricate Web of Phytohormone Signalling in Modulating Root System Architecture.International journal of molecular sciences · 2021Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
WRINKLED1 (WRI1) is a key transcriptional regulator of fatty acid biosynthesis genes in diverse oil-containing tissues. Loss of function of Arabidopsis WRI1 leads to a reduction in the expression of genes for fatty acid biosynthesis and glycolysis, and concomitant strong reduction of seed oil content. The wri1-1 loss-of-function mutant shows reduced primary root growth and decreased acidification of the growth medium. The content of a conjugated form of the plant growth hormone auxin, indole-3-acetic acid (IAA)-Asp, was higher in wri1-1 plants compared with the wild-type. GH3.3, a gene encoding an enzyme involved in auxin degradation, displayed higher expression in the wri1-1 mutant. EMSAs demonstrated that AtWRI1 bound to the promoter of GH3.3. Specific AtWRI1-binding motifs were identified in the promoter of GH3.3. In addition, wri1-1 displayed decreased auxin transport. Expression of some PIN genes, which encode IAA carrier proteins, was reduced in wri1-1 plants as well. Correspondingly, AtWRI1 bound to the promoter regions of some PIN genes. It is well known that auxin exerts its maximum effects at a specific, optimal concentration in roots requiring a finely balanced auxin homeostasis. This process appears to be disrupted when the expression of WRI1 and in turn a subset of its target genes are misregulated, highlighting a role for WRI1 in root auxin homeostasis.
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