ArticleNucleic acids research2017
Insights into interplay between rexinoid signaling and myogenic regulatory factor-associated chromatin state in myogenic differentiation.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Cistromic insight into the association of retinoid X receptor with MyoD and CTCF in proliferating myoblasts.Scientific reports · 2025Article
- Exploring the Regulation ofJournal of developmental biology · 2025Article
- Reduced myotube diameter induced by combined inhibition of transforming growth factor-β type I receptors Acvr1b and Tgfbr1 is associated with enhanced β1-syntrophin expression.Journal of cellular physiology · 2024Article
- Emerging role of HDAC11 in skeletal muscle biology.Frontiers in cell and developmental biology · 2024Article
- Article
- Regulation of Dystroglycan Gene Expression in Early Myoblast Differentiation.Frontiers in cell and developmental biology · 2022Article
- Chromatin state distribution of residue-specific histone acetylation in early myoblast differentiation.Journal of big data · 2022Article
- Multi-Omics Approach to Dissect the Mechanisms of Rexinoid Signaling in Myoblast Differentiation.Frontiers in pharmacology · 2021Article
- Dietary Supplementation With Chlorogenic Acid Derived FromFrontiers in physiology · 2021Article
- Dissecting myogenin-mediated retinoid X receptor signaling in myogenic differentiation.Communications biology · 2020Article
- Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Regulation of Intronic Polyadenylation by PCF11 Impacts mRNA Expression of Long Genes.Cell reports · 2019Article
- Analysis of alternative cleavage and polyadenylation in mature and differentiating neurons using RNA-seq data.Quantitative biology (Beijing, China) · 2018Article
- A novel retinoid X receptor agonist, UAB30, inhibits rhabdomyosarcoma cells in vitro.The Journal of surgical research · 2018Article
- Loci-specific histone acetylation profiles associated with transcriptional coactivator p300 during early myoblast differentiation.Epigenetics · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While skeletal myogenesis is tightly coordinated by myogenic regulatory factors including MyoD and myogenin, chromatin modifications have emerged as vital mechanisms of myogenic regulation. We have previously established that bexarotene, a clinically approved agonist of retinoid X receptor (RXR), promotes the specification and differentiation of skeletal muscle lineage. Here, we examine the genome-wide impact of rexinoids on myogenic differentiation through integral RNA-seq and ChIP-seq analyses. We found that bexarotene promotes myoblast differentiation through the coordination of exit from the cell cycle and the activation of muscle-related genes. We uncovered a new mechanism of rexinoid action which is mediated by the nuclear receptor and largely reconciled through a direct regulation of MyoD gene expression. In addition, we determined a rexinoid-responsive residue-specific histone acetylation at a distinct chromatin state associated to MyoD and myogenin. Thus, we provide novel molecular insights into the interplay between RXR signaling and chromatin states pertinent to myogenic programs in early myoblast differentiation.
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