ArticleCerebral cortex (New York, N.Y. : 1991)2018
Electrocorticographic Encoding of Human Gait in the Leg Primary Motor Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Targeting auditory verbal hallucinations in schizophrenia: effective connectivity changes induced by low-frequency rTMS.Translational psychiatry · 2024Trial
- Multi-session anodal transcranial direct current stimulation enhances lower extremity functional performance in healthy older adults.Experimental brain research · 2020Trial
- Neurovascular dysfunction in cerebral small vessel disease: impact on cognition and depression using arterial spin labeling and resting-state fMRI.Brain imaging and behavior · 2026Article
- Macroscale Gradient-Informed Neural Oscillation Topography in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- At-home movement state classification using totally implantable cortical-basal ganglia neural interface.Science advances · 2026Article
- Could adaptive deep brain stimulation treat freezing of gait in Parkinson's disease?Journal of neurology · 2025Review
- Mobile neuroimaging: What we have learned about the neural control of human walking, with an emphasis on EEG-based research.Neuroscience and biobehavioral reviews · 2024Review
- Electrical brain activity during human walking with parametric variations in terrain unevenness and walking speed.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Foot orientation and trajectory variability in locomotion: Effects of real-world terrain.PloS one · 2024Article
- Mobile cognition: imaging the human brain in the 'real world'.Nature reviews. Neuroscience · 2023Review
- Article
- Robust cortical encoding of 3D tongue shape during feeding in macaques.Nature communications · 2023Article
- Hotspots and trends in fNIRS disease research: A bibliometric analysis.Frontiers in neuroscience · 2023Review
- Human upper extremity motor cortex activity shows distinct oscillatory signatures for stereotyped arm and leg movements.Frontiers in human neuroscience · 2023Article
- A Neurosurgical Functional Dissection of the Middle Precentral Gyrus during Speech Production.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- Review
- Cortical phase-amplitude coupling is key to the occurrence and treatment of freezing of gait.Brain : a journal of neurology · 2022Article
- Specific age-correlated activation of top hierarchical motor control areas during gait-like plantar stimulation: An fMRI study.Human brain mapping · 2022Article
- Artifact propagation in subdural cortical electrostimulation: Characterization and modeling.Frontiers in neuroscience · 2022Article
- Early decreases in cortical mid-gamma peaks coincide with the onset of motor deficits and precede exaggerated beta build-up in rat models for Parkinson's disease.Neurobiology of disease · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
While prior noninvasive (e.g., electroencephalographic) studies suggest that the human primary motor cortex (M1) is active during gait processes, the limitations of noninvasive recordings make it impossible to determine whether M1 is involved in high-level motor control (e.g., obstacle avoidance, walking speed), low-level motor control (e.g., coordinated muscle activation), or only nonmotor processes (e.g., integrating/relaying sensory information). This study represents the first invasive electroneurophysiological characterization of the human leg M1 during walking. Two subjects with an electrocorticographic grid over the interhemispheric M1 area were recruited. Both exhibited generalized γ-band (40-200 Hz) synchronization across M1 during treadmill walking, as well as periodic γ-band changes within each stride (across multiple walking speeds). Additionally, these changes appeared to be of motor, rather than sensory, origin. However, M1 activity during walking shared few features with M1 activity during individual leg muscle movements, and was not highly correlated with lower limb trajectories on a single channel basis. These findings suggest that M1 primarily encodes high-level gait motor control (i.e., walking duration and speed) instead of the low-level patterns of leg muscle activation or movement trajectories. Therefore, M1 likely interacts with subcortical/spinal networks, which are responsible for low-level motor control, to produce normal human walking.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.