ArticleCerebral cortex (New York, N.Y. : 1991)2018
Local-Global Parcellation of the Human Cerebral Cortex from Intrinsic Functional Connectivity MRI.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2,256 papers, 2 of them syntheses that pooled it.
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Who cites it
2,256 citing papers in PubMed, 2 syntheses or guidelines pooled it.
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- Go with the (Blood) Flow: A Systematic Review on the Relationship Between Dynamic Functional Connectivity and Information Processing Speed.Neuropsychology review · 2026Pooled it
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- rTMS modulates early AD progression via synergistic brain network reorganization and peripheral biomarker dynamics.GeroScience · 2026Trial
- Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin.Molecular psychiatry · 2026Trial
- Nine minutes is enough: An accelerated fMRI protocol for reliable connectivity mapping in healthy young adults.Dialogues in clinical neuroscience · 2027Article
- Mapping topological abnormalities in cortical similarity networks to schizophrenia-associated gene expression.Dialogues in clinical neuroscience · 2026Article
- Distinct Representations of Irrelevant Emotional Information in the Visual Network Are Associated With Psychopathology in Youth.Biological psychiatry global open science · 2026Article
- Widespread synaptic density loss in schizophrenia follows molecular and network architecture.Molecular psychiatry · 2026Article
- Oscillatory dynamics within fronto-insular-parietal networks integrate thermosensory signals into body ownership.iScience · 2026Article
- Intrinsic functional architecture predicts remote motor cortical excitability changes induced by intermittent theta-burst stimulation.iScience · 2026Article
- Microglial dynamics associate with the spatial pattern of tau deposition in early Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Trait-relevant movies amplify neuroticism-associated brain responses.Communications psychology · 2026Article
- Distinct electroencephalography alpha-band rhythms map macroscale brain gradients.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Detailed Analysis of Intraretinal Layers and Their Correlation to Brain Structures in Normal Healthy Aging.Translational vision science & technology · 2026Article
- Different functional connectivity gradients reflect aging and Alzheimer's disease.Nature neuroscience · 2026Article
- Endocannabinoids Mediate Racial/Ethnic Discrimination Prediction of Posttraumatic Stress Disorder Symptoms Moderated by Resting-State Functional Connectivity in Black and African American Individuals.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Individualised Structural and Functional Frontostriatal Connectivity Mapping in Adult ADHD.Human brain mapping · 2026Article
- Spatial Collinearity Constrains Multivariate Molecular-Enriched Network Estimation.Human brain mapping · 2026Article
- Sex-specific brain reserve and progression from mild cognitive impairment to Alzheimer's disease dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
2,196 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
A central goal in systems neuroscience is the parcellation of the cerebral cortex into discrete neurobiological "atoms". Resting-state functional magnetic resonance imaging (rs-fMRI) offers the possibility of in vivo human cortical parcellation. Almost all previous parcellations relied on 1 of 2 approaches. The local gradient approach detects abrupt transitions in functional connectivity patterns. These transitions potentially reflect cortical areal boundaries defined by histology or visuotopic fMRI. By contrast, the global similarity approach clusters similar functional connectivity patterns regardless of spatial proximity, resulting in parcels with homogeneous (similar) rs-fMRI signals. Here, we propose a gradient-weighted Markov Random Field (gwMRF) model integrating local gradient and global similarity approaches. Using task-fMRI and rs-fMRI across diverse acquisition protocols, we found gwMRF parcellations to be more homogeneous than 4 previously published parcellations. Furthermore, gwMRF parcellations agreed with the boundaries of certain cortical areas defined using histology and visuotopic fMRI. Some parcels captured subareal (somatotopic and visuotopic) features that likely reflect distinct computational units within known cortical areas. These results suggest that gwMRF parcellations reveal neurobiologically meaningful features of brain organization and are potentially useful for future applications requiring dimensionality reduction of voxel-wise fMRI data. Multiresolution parcellations generated from 1489 participants are publicly available (https://github.com/ThomasYeoLab/CBIG/tree/master/stable_projects/brain_parcellation/Schaefer2018_LocalGlobal).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.