ArticleCerebral cortex (New York, N.Y. : 1991)2018
X-Chromosome Effects on Attention Networks: Insights from Imaging Resting-State Networks in Turner Syndrome.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Sex chromosome aneuploidy impacts on human gene expression and regulation: a systematic review.Molecular medicine (Cambridge, Mass.) · 2025Pooled it
- White matter microstructure and functional connectivity in the brains of infants with Turner syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Resting-state functional connectivity in adults with 47,XXX: a 7 Tesla MRI study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Cross-attractor repertoire provides new perspective on structure-function relationship in the brain.NeuroImage · 2022Article
- The Hypothesis of the Prolonged Cell Cycle in Turner Syndrome.Journal of developmental biology · 2022Review
- Empathic Accuracy in Adolescent Girls with Turner Syndrome.Journal of autism and developmental disorders · 2022Article
- Altered canonical and striatal-frontal resting state functional connectivity in children with pathogenic variants in the Ras/mitogen-activated protein kinase pathway.Molecular psychiatry · 2022Article
- Resting-State Functional Connectivity and Psychopathology in Klinefelter Syndrome (47, XXY).Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Effects of hypogonadism on brain development during adolescence in girls with Turner syndrome.Human brain mapping · 2019Article
- X-Chromosome Insufficiency Alters Receptive Fields across the Human Early Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- High body mass index, brain metabolism and connectivity: an unfavorable effect in elderly females.Aging · 2019Article
- PTPN11 Gain-of-Function Mutations Affect the Developing Human Brain, Memory, and Attention.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Reversal Learning Performance in the XYFrontiers in behavioral neuroscience · 2019Article
- Sex differences in psychiatric disorders: what we can learn from sex chromosome aneuploidies.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Attention deficit hyperactivity disorder (ADHD) is strongly affected by sex, but sex chromosomes' effect on brain attention networks and cognition are difficult to examine in humans. This is due to significant etiologic heterogeneity among diagnosed individuals. In contrast, individuals with Turner syndrome (TS), who have substantially increased risk for ADHD symptoms, share a common genetic risk factor related to the absence of the X-chromosome, thus serving as a more homogeneous genetic model. Resting-state functional MRI was employed to examine differences in attention networks between girls with TS (n = 40) and age- sex- and Tanner-matched controls (n = 33). We compared groups on resting-state functional connectivity measures from data-driven independent components analysis (ICA) and hypothesis-based seed analysis. Using ICA, reduced connectivity was observed in both frontoparietal and dorsal attention networks. Similarly, using seeds in the bilateral intraparietal sulcus (IPS), reduced connectivity was observed between IPS and frontal and cerebellar regions. Finally, we observed a brain-behavior correlation between IPS-cerebellar connectivity and cognitive attention measures. These findings indicate that X-monosomy contributes affects to attention networks and cognitive dysfunction that might increase risk for ADHD. Our findings not only have clinical relevance for girls with TS, but might also serve as a biological marker in future research examining the effects of the intervention that targets attention skills.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.