Evidence map›Paper›PMID 28981554›Full record

ArticleThrombosis and haemostasis2017

Extracellular Cyclophilin A Augments Platelet-Dependent Thrombosis and Thromboinflammation.

Saskia N I von Ungern-Sternberg, Sebastian Vogel, Britta Walker-Allgaier, Sascha Geue, Andreas Maurer, Anna-Maria Wild, Patrick Münzer, Madhumita Chatterjee, David Heinzmann, Elisabeth Kremmer and 7 more

Open access · greenAbstract read
In one paragraph

Article in Thrombosis and haemostasis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Non-Immunosuppressive Cyclophilin Inhibitors.Angewandte Chemie (International ed. in English) · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Saskia N I von Ungern-SternbergMedizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, Tübingen, Germany.
Sebastian VogelMedizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, Tübingen, Germany.
Britta Walker-AllgaierMedizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, Tübingen, Germany.
Sascha GeueMedizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, Tübingen, Germany.
Andreas MaurerWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls-Universität Tübingen, Tübingen, Germany.
Anna-Maria WildWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls-Universität Tübingen, Tübingen, Germany.
Patrick MünzerMedizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, Tübingen, Germany.
Madhumita ChatterjeeMedizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, Tübingen, Germany.
David HeinzmannMedizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, Tübingen, Germany.
Elisabeth KremmerHelmholtz Zentrum München, Institut für Molekulare Immunologie, München, Germany.
Oliver BorstMedizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, Tübingen, Germany.
Patricia LoughranDepartment of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Alma ZerneckeInstitut für Experimentelle Biomedizin, Universitätsklinikum Würzburg, Germany.
Matthew D NealDepartment of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Timothy R BilliarDepartment of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Meinrad GawazMedizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, Tübingen, Germany.
Peter SeizerMedizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, Tübingen, Germany.
University of Tübingen · DEUniversity of Pittsburgh · USHelmholtz Zentrum München · DE

Funding

Mechanistic Elucidation and Targeted Therapy of Platelet Dysfunction After TraumaR35GM119526 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEAL, MATTHEW D · 2016 to 2025
$3.9M
Request for a Nikon A1 confocal microscopeS10OD019973 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2015 to 2015
$358k
NIGMS NIH HHS R35 GM119526NIH HHS S10 OD019973
6 · The paper itself

Abstract

Cyclophilin A (CyPA) is involved in the pathophysiology of several inflammatory and cardiovascular diseases. To our knowledge, there is no specific inhibitor targeting extracellular CyPA without affecting other extracellular cyclophilins or intracellular CyPA functions. In this study, we developed an antibody-based inhibitor of extracellular CyPA and analysed its effects

Indexed as

Platelet ActivationAnimalsAntibodies, MonoclonalAntibodies, NeutralizingAnti-Inflammatory AgentsBasiginBlood CoagulationBlood PlateletsCell AdhesionCell MovementCells, CulturedCyclophilin ADisease Models, AnimalFibrinolytic AgentsHumansInflammationAntibodies, MonoclonalAntibodies, NeutralizingAnti-Inflammatory AgentsBasiginBSG protein, humanBsg protein, mouseCyclophilin AFibrinolytic Agents

Identifiers

PMID28981554
PMCPMC5885247
OpenAlexW2761792853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.