Evidence map›Paper›PMID 28981543›Full record

Trial reportPloS one2017

Bacterial colonization patterns in daily chlorhexidine care at the exit site in peritoneal dialysis patients-A prospective, randomized controlled trial.

Hsi-Hao Wang, Shih-Yuan Hung, Min-Yu Chang, Yi-Che Lee, Hsiu-Fang Lin, Tsun-Mei Lin, Su-Pen Yang, Hsi-Hsun Lin, Su-Ching Yang, Jiun-Ling Wang

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02446158 (A Randomized Trial of Daily Chlorhexidine Care at the Exit Site in Peritoneal Dialysis Patients for Bacterial Decolonization and Prevention of Infection), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02446158 phase4completednot on this map

A Randomized Trial of Daily Chlorhexidine Care at the Exit Site in Peritoneal Dialysis Patients for Bacterial Decolonization and Prevention of Infection

TypeinterventionalSponsorE-DA HospitalRan2010 to 2011Enrolled89ConditionsPeritoneal Dialysis Catheter Exit Site InfectionArmsChlorhexidine gluconate
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hsi-Hao WangInternal Medicine Department, E-DA Hospital, Kaohsiung, Taiwan.
Shih-Yuan HungInternal Medicine Department, E-DA Hospital, Kaohsiung, Taiwan.
Min-Yu ChangInternal Medicine Department, E-DA Hospital, Kaohsiung, Taiwan.
Yi-Che LeeInternal Medicine Department, E-DA Hospital, Kaohsiung, Taiwan.
Hsiu-Fang LinDepartment of Laboratory Medicine, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan.
Tsun-Mei LinDepartment of Laboratory Medicine, E-DA Hospital/I-Shou University, Kaohsiung, Taiwan.
Su-Pen YangInternal Medicine Department, E-DA Hospital, Kaohsiung, Taiwan.
Hsi-Hsun LinInternal Medicine Department, E-DA Hospital, Kaohsiung, Taiwan.
Su-Ching YangDepartment of Nursing, National Tainan Institute of Nursing, Tainan, Taiwan.
Jiun-Ling WangDepartment of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; Department of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID http://orcid.org/0000-0002-9465-8692

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial colonization patterns in daily chlorhexidine care at the exit site in peritoneal dialysis (PD) patients were not known. We performed a prospective, randomized controlled trial enrolling 89 PD patients. After stratification by initial Staphylococcus aureus (SA) carrier status, patients were randomly assigned to receive daily 4% chlorhexidine care (intervention group) or normal saline (control group) at the exit site. Monthly, we cultured bacteria from the exit site and nasal swabs for 1 year. The SA colonization rates at exit site at 6 and 12 months were significantly lower in the intervention group than the control group (5.0% vs. 22.9%, p = 0.023 and 8.6% vs. 28.1%, p = 0.037 for 6 and 12 months, respectively). The Methicillin-resistant SA (MRSA) colonization rate at exit site at 6 months was similar (5.7% vs. 2.5%,p = 0.596) in control and intervention group, but significantly lower in the intervention group than the control group at exit site at 12months (0% vs. 12.5%, p = 0.047). The gram-negative bacilli (GNB) colonization rates were similar between the intervention and control groups at 6 and 12 months. Genotyping of all MRSA isolates showed ST (sequence type) 59 was the most predominant clone. In conclusion, chlorhexidine care at the exit site in PD patients may be a good strategy for SA and MRSA decolonization.

trial registrationClinicalTrials.gov NCT02446158.

Indexed as

Peritoneal DialysisChlorhexidineHumansProspective StudiesStaphylococcus aureusChlorhexidine

Identifiers

PMID28981543
PMCPMC5628800

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.