ArticlePloS one2017
Predictors of transitions in frailty severity and mortality among people aging with HIV.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Systematic review and meta-analysis of the association between smoking and the incidence of frailty.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2019Pooled it
- Predictors of frailty trajectories among people with HIV.AIDS (London, England) · 2025Observational
- Alcohol Use and Its Associations With Frailty, Fractures, and Falls Among Older Adults With HIV.Alcohol research : current reviews · 2025Review
- Review
- Food insecurity and frailty among women with and without HIV in the United States: a cross-sectional analysis.Journal of the International AIDS Society · 2021Article
- Review
- Neurocognitive status and risk of mortality among people living with human immunodeficiency virus: an 18-year retrospective cohort study.Scientific reports · 2021Article
- Frailty index transitions over eight years were frequent in The Irish Longitudinal Study on Ageing.HRB open research · 2021Article
- Geriatric Syndromes in People Living with HIV Associated with Ageing and Increasing Comorbidities: Implications for Neurocognitive Complications of HIV Infection.Current topics in behavioral neurosciences · 2021Article
- Comorbidities in Older Persons with Controlled HIV Infection: Correlations with Frailty Index Subtypes.AIDS patient care and STDs · 2020Article
- Frailty in People Living with HIV.Current HIV/AIDS reports · 2020Review
- Research priorities for rehabilitation and aging with HIV: a framework from the Canada-International HIV and Rehabilitation Research Collaborative (CIHRRC).AIDS research and therapy · 2020Article
- Pilot study assessing the Rotterdam Healthy Aging Score in a cohort of HIV-positive adults in Toronto, Canada.AIDS (London, England) · 2020Article
- Diagnostic Issues of Asymptomatic Neurosyphilis in HIV-Positive Patients: A Retrospective Study.Brain sciences · 2019Article
- Frailty: a new vulnerability indicator in people aging with HIV.European geriatric medicine · 2019Review
- Older HIV-infected adults: complex patients- geriatric syndromes (II).European geriatric medicine · 2019Article
- Frailty in people living with HIV.AIDS research and therapy · 2018Review
- Cognitive Performance and Frailty in Older HIV-Positive Adults.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- Frailty, nutrition-related parameters, and mortality across the adult age spectrum.BMC medicine · 2018Article
- Psychosocial Correlates of Frailty Among HIV-Infected and HIV-Uninfected Adults.Behavioral medicine (Washington, D.C.)Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeople aging with HIV show variable health trajectories. Our objective was to identify longitudinal predictors of frailty severity and mortality among a group aging with HIV.
methodsExploratory analyses employing a multistate transition model, with data from the prospective Modena HIV Metabolic Clinic Cohort Study, based in Northern Italy, begun in 2004. Participants were followed over four years from their first available visit. We included all 963 participants (mean age 46.8±7.1; 29% female; 89% undetectable HIV viral load; median current CD4 count 549, IQR 405-720; nadir CD4 count 180, 81-280) with four-year data. Frailty was quantified using a 31-item frailty index. Outcomes were frailty index score or mortality at four-year follow-up. Candidate predictor variables were baseline frailty index score, demographic (age, sex), HIV-disease related (undetectable HIV viral load, current CD4+ T-cell count, nadir CD4 count, duration of HIV infection, and duration of antiretroviral therapy [ARV] exposure), and behavioral factors (smoking, injection drug use (IDU), and hepatitis C virus co-infection).
resultsFour-year mortality was 3.0% (n = 29). In multivariable analyses, independent predictors of frailty index at follow-up were baseline frailty index (RR 1.06, 95% CI 1.05-1.07), female sex (RR 0.93, 95% CI 0.87-0.98), nadir CD4 cell count (RR 0.96, 95% CI 0.93-0.99), duration of HIV infection (RR 1.06, 95% CI 1.01-1.12), duration of ARV exposure (RR 1.08, 95% CI 1.02-1.14), and smoking pack-years (1.03, 1.01-1.05). Independent predictors of mortality were baseline frailty index (OR 1.19, 1.02-1.38), current CD4 count (0.34, 0.20-0.60), and IDU (2.89, 1.30-6.42).
conclusionsDemographic, HIV-disease related, and social and behavioral factors appear to confer risk for changes in frailty severity and mortality among people aging with HIV.
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