ArticlePloS one2017
Glycosylation of 6-methylflavone by the strain Isaria fumosorosea KCH J2.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 43 citations in OpenAlex.
- 6-methylflavone exerts selective antimycobacterial activity with membrane energetics disruption and demonstrates therapeutic potential againstMicrobiology spectrum · 2026Article
- Fungal Biotransformation of Chloroflavanones and Antimicrobial Activity of Parent Compounds and Derived Products.International journal of molecular sciences · 2025Article
- Antimicrobial activity of new glycoside derivatives of chloroflavones obtained by fungal biotransformation.Scientific reports · 2025Article
- Methyl Derivatives of Flavone as Potential Anti-Inflammatory Compounds.International journal of molecular sciences · 2025Article
- Antimicrobial Activity of Chalcones with a Chlorine Atom and Their Glycosides.International journal of molecular sciences · 2024Article
- Synthesis, fungal biotransformation, and evaluation of the antimicrobial potential of chalcones with a chlorine atom.Scientific reports · 2024Article
- Antimicrobial Properties of Flavonoid Derivatives with Bromine, Chlorine, and Nitro Group Obtained by Chemical Synthesis and Biotransformation Studies.International journal of molecular sciences · 2024Article
- Article
- Multienzymatic biotransformation of flavokawain B by entomopathogenic filamentous fungi: structural modifications and pharmacological predictions.Microbial cell factories · 2024Article
- Glycosylation of Quercetin by Selected Entomopathogenic Filamentous Fungi and Prediction of Its Products' Bioactivity.International journal of molecular sciences · 2023Article
- Biotransformation of Flavonoids with -NOInternational journal of molecular sciences · 2023Article
- Hydroxylation of Progesterone and Its Derivatives by the Entomopathogenic StrainInternational journal of molecular sciences · 2022Article
- Glycosylation of Methylflavonoids in the Cultures of Entomopathogenic Filamentous Fungi as a Tool for Obtaining New Biologically Active Compounds.International journal of molecular sciences · 2022Article
- 4'-Methylflavanone Glycosides Obtained Using Biotransformation in the Entomopathogenic Filamentous Fungi Cultures as Potential Anticarcinogenic, Antimicrobial, and Hepatoprotective Agents.International journal of molecular sciences · 2022Article
- Fungal Biotransformation of 2'-Methylflavanone and 2'-Methylflavone as a Method to Obtain Glycosylated Derivatives.International journal of molecular sciences · 2021Article
- New Glycosylated Dihydrochalcones Obtained by Biotransformation of 2'-Hydroxy-2-methylchalcone in Cultures of Entomopathogenic Filamentous Fungi.International journal of molecular sciences · 2021Article
- Simple and Rapid Method for Wogonin Preparation and Its Biotransformation.International journal of molecular sciences · 2021Article
- Model Application of Entomopathogenic Fungi as Alternatives to Chemical Pesticides: Prospects, Challenges, and Insights for Next-Generation Sustainable Agriculture.Frontiers in plant science · 2021Review
- The Callus ofMolecules (Basel, Switzerland) · 2020Article
- Naturally Occurring Flavonoids and Isoflavonoids and Their Microbial Transformation: A Review.Molecules (Basel, Switzerland) · 2020Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Entomopathogenic fungi are known for their ability to carry out glycosylation of flavonoids, which usually results in the improvement of their stability and bioavailability. In this study we used a newly isolated strain of the entomopathogenic filamentous fungus Isaria fumosorosea KCH J2 as a biocatalyst. Our aim was to evaluate its ability to carry out the biotransformation of flavonoids and to obtain new flavonoid derivatives. The fungus was isolated from a spider's carcass and molecularly identified using analysis of the ITS1-ITS2 rDNA sequence. As a result of biotransformation of 6-methylflavone two new products were obtained: 6-methylflavone 8-O-β-D-(4"-O-methyl)-glucopyranoside and 6-methylflavone 4'-O-β-D-(4"-O-methyl)-glucopyranoside. Chemical structures of the products were determined based on spectroscopic methods (1H NMR, 13C NMR, COSY, HMBC, HSQC). Our research allowed us to discover a new species of filamentous fungus capable of carrying out glycosylation reactions and proved that I. fumosorosea KCH J2 is an effective biocatalyst for glycosylation of flavonoid compounds. For the first time we describe biotransformations of 6-methylflavone and the attachment of the sugar unit to the flavonoid substrate having no hydroxyl group. The possibility of using flavonoid aglycones is often limited by their low bioavailability due to poor solubility in water. The incorporation of a sugar unit improves the physical properties of tested compounds and thus increases the chance of using them as pharmaceuticals.
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