Evidence map›Paper›PMID 28981339›Full record

ReviewBrain injury2017

Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions.

Ibolja Cernak, Donald G Stein, Gregory A Elder, Stephn Ahlers, Kenneth Curley, Ralph G DePalma, John Duda, Milos Ikonomovic, Grant L Iverson, Firas Kobeissy and 7 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain injury, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ibolja Cernaka Military and Veterans' Clinical Rehabilitation Research, Faculty of Rehabilitation Medicine , University of Alberta , Edmonton , Alberta , Canada.ORCID http://orcid.org/0000-0003-3214-698X
Donald G Steinb Emory School of Medicine , Department of Emergency Medicine Brain Research Laboratory , Atlanta , Georgia , USA.
Gregory A Elderc James J. Peters VA Medical Center , Bronx , NY , USA.
Stephn Ahlerse Operational and Undersea Medicine, Naval Medical Research Center , Silver Spring , MD , USA.
Kenneth Curleyf Iatrikos Research and Development Strategies, LLC , Tampa , FL , USA.
Ralph G DePalmah VA ORD & Department of Surgery , Uniformed Services University of the Health Sciences, Office of Research and Development , Washington , DC , USA.
John Dudai Parkinson's Disease Research, Education and Clinical Center, Philadelphia VA Medical Center; and Department of Neurology , Perelman School of Medicine, University of Pennsylvania , Philadelphia , PA , USA.
Milos Ikonomovicj Department of Neurology , University of Pittsburgh , Pittsburgh , PA , USA.
Grant L Iversonk Neuropsychology Outcome Assessment Laboratory, Department of Physical Medicine and Rehabilitation , Harvard Medical School , Boston , MA , USA.
Firas Kobeissyl Psychoproteomics and Nanotechnology Research Center, Department of Psychiatry , The Evelyn F and William L. McKnight Brain Institute, University of Florida , Gainesville , FL , USA.
Vassilis E Koliatsosm Department of Pathology (Neuropathology) and Neurology , Johns Hopkins School of Medicine , Baltimore , MD , USA.
Michael J Leggierin DoD Blast Injury Research Program Coordinating Office, U.S. Army Medical Research and Materiel Command , Ft Detrick , MD , USA.
Anthony M Pacificoo Alzheimer's and Epilepsy Research Programs, Congressionally Directed Medical Research Programs; US Department of Health and Human Services , Telemedicine and Advanced Technology Research Center , Fort Detrick , MD , USA.
Douglas H Smithp The Robert A. Groff Professor of Neurosurgery/Research and Education, Department of Neurosurgery/PENN's Center for Brain Injury and Repair , University of Pennsylvania , Philadelphia , PA , USA.
Raymond Swansonq Department of Neurology , University of California San Francisco; and Neurology Service, SFVAMC , San Francisco , CA , USA.
Floyd J Thompsonr Brain Rehabilitation Research Center, Malcom Randall VAMC; Physiological Sciences and Professor Emeritus, Neuroscience, University of Florida , Gainesville , FL , USA.
Frank C Tortellas Branch of Brain Trauma Neuroprotection and Neurorestoration, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research ; Silver Spring , MD , USA.

Funding

Neuropathological Characterization of 'CTE'R01NS094003 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Douglas Hamilton Smith, William Stewart · 2016 to 2026
$5.1M
Detection and Mechanisms of Mild Traumatic Brain InjuryR01NS092398 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SMITH, DOUGLAS HAMILTON · 2015 to 2019
$1.9M
The Neurobiology of Blast-Related Brain Injury in a Rat Model of mTBII01RX000996 · VA · JAMES J PETERS VA MEDICAL CENTER · PI ELDER, GREGORY A. · 2014 to 2018
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NINDS NIH HHS R01 NS092398NINDS NIH HHS R01 NS094003RRD VA I01 RX000996
6 · The paper itself

Abstract

As a follow-up to the 2008 state-of-the-art (SOTA) conference on traumatic brain injuries (TBIs), the 2015 event organized by the United States Department of Veterans Affairs (VA) Office of Research and Development (ORD) analysed the knowledge gained over the last 7 years as it relates to basic scientific methods, experimental findings, diagnosis, therapy, and rehabilitation of TBIs and blast-induced neurotraumas (BINTs). The current article summarizes the discussions and recommendations of the scientific panel attending the Preclinical Modeling and Therapeutic Development Workshop of the conference, with special emphasis on factors slowing research progress and recommendations for ways of addressing the most significant pitfalls.

Indexed as

Disease Models, AnimalMilitary PersonnelAnimalsBlast InjuriesBrain Injuries, TraumaticForecastingHumansUnited StatesUnited States Department of Veterans Affairsblast-induced neurotraumaconferenceexperimental modelspreclinical researchtraumatic brain injuryUnited States Department of Veterans Affairs

Identifiers

PMID28981339
PMCPMC9351990

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.