ArticleMolecular nutrition & food research2017
Nutrikinetics of Isoflavone Metabolites After Fermented Soybean Product (Cheonggukjang) Ingestion in Ovariectomized Mice.
Article in Molecular nutrition & food research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Glycitin in Soy Beans: A Mine of Their Structures, Functions, and Potential Applications.Foods (Basel, Switzerland) · 2025Review
- Characterization of fermented foods: bone health.Frontiers in nutrition · 2025Review
- Comparison in Bioactive Compounds and Antioxidant Activity ofFoods (Basel, Switzerland) · 2024Article
- Observational
- The Interaction between Flavonoids and Intestinal Microbes: A Review.Foods (Basel, Switzerland) · 2023Review
- Metagenomic-Metabolomic Mining ofFrontiers in microbiology · 2022Article
- Current Perspectives on the Physiological Activities of Fermented Soybean-Derived Cheonggukjang.International journal of molecular sciences · 2021Review
- Protection of Fatty Liver by the Intake of Fermented Soybean Paste,Foods (Basel, Switzerland) · 2021Article
- Validation of soy isoflavone intake and its health effects: a review of the development of exposure biomarkers.Nutrition research and practice · 2021Review
- Article
- Is There Such a Thing as "Anti-Nutrients"? A Narrative Review of Perceived Problematic Plant Compounds.Nutrients · 2020Review
- Article
- Nutrikinetic study of fermented soybean paste (Nutrition research and practice · 2020Article
- Identification of equol-7-glucuronide-4'-sulfate, monoglucuronides and monosulfates in human plasma of 2 equol producers after administration ofPharmacology research & perspectives · 2019Article
- Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Molecular Mechanisms of Action of Genistein in Cancer: Recent Advances.Frontiers in pharmacology · 2019Review
- Nutrikinetics of Isoflavone Metabolites After Fermented Soybean Product (Cheonggukjang) Ingestion in Ovariectomized Mice.Molecular nutrition & food research · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
scopeCheonggukjang (CGJ) is a soybean-based quick-fermented food popular in Korea that contains a variety of biologically active compounds including isoflavones and saponins. Isoflavone bioavailability may be important for the bone health of postmenopausal women; therefore, the aim of this study is to evaluate the influence of fermentation on the isoflavone metabolite nutrikinetic profile after single dose CGJ or unfermented soybean administration in ovariectomized (OVX) and sham mice. METHODS AND
resultsWe identify 34 isoflavone metabolites using UPLC-QTOF-MS and analyze their nutrikinetics at different time points (0.25, 0.5, 1, 2, 4, 8, 16, and 24 h) to understand their fermentation- and OVX-mediated time-dependent concentration changes. Nutrikinetics analysis shows that genistein, daidzein, genistein 4'-sulfate, dihydrodaidzein sulfate, equol 4'-sulfate, and equol-7-glucuronide are present at high concentrations in all groups based on area-under-the-curve analysis. OVX mice appear to show lower isoflavone bioavailability than mice in the sham group. CGJ enhances various isoflavone metabolite bioavailability including genistein, 3-hydroxygenistein, and equol 7-glucuronide, compared to the unfermented soybean-treated group. Among these metabolites, intact isoflavones, 3-hydroxygenistein, genistein 4'-sulfate, and equol 7-glucuronide promote osteoblastogenesis and inhibit osteoclast formation.
conclusionsCGJ has good isoflavone bioavailability and may be beneficial for the bone health of postmenopausal women.
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