Evidence map›Paper›PMID 28981105›Full record

ArticleCell death & disease2017

Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration.

Luigi Racioppi, William Lento, Wei Huang, Stephanie Arvai, Phuong L Doan, Jeffrey R Harris, Fernando Marcon, Helder I Nakaya, Yaping Liu, Nelson Chao

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Hematopoietic Stem Cell Hierarchies as Novel Biomarkers of Drug Response in Myelodysplastic Syndromes and Acute Myeloid Leukemia.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. MBTD1 preserves adult hematopoietic stem cell pool size and function.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Molecular Mechanisms Underlying CaInternational journal of molecular sciences · 2022
    Review
  15. Review
  16. Differential activation of CaNPJ Regenerative medicine · 2021
    Article
  17. Increasing cytosolic CaStem cell research · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Luigi RacioppiDivision of Hematological Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
William LentoDivision of Hematological Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Wei HuangDivision of Hematological Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Stephanie ArvaiDivision of Hematological Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Phuong L DoanDivision of Hematological Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Jeffrey R HarrisDivision of Hematological Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Fernando MarconDepartment of Pathophysiology and Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Helder I NakayaDepartment of Pathophysiology and Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Yaping LiuDivision of Hematological Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Nelson ChaoDivision of Hematological Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Duke Medical Center · USUniversidade de São Paulo · BR

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI DONNA NIEDZWIECKI · 1985 to 2026
$174.8M
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Sample Engineering CoreU19AI067773 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FORNACE, ALBERT J · 2005 to 2024
$105.4M
Somatostatin analogues as countermeasures against intestinal radiation toxicityU19AI067798 · NIAID · DUKE UNIVERSITY · PI CHAO, NELSON J. · 2005 to 2024
$82.1M
Role of ErbB receptor signaling in regulating normal and leukemic stem cell fateK08CA184552 · NCI · DUKE UNIVERSITY · PI DOAN, PHUONG LINH · 2014 to 2018
$639k
NCI NIH HHS K08 CA184552NCI NIH HHS P30 CA014236NCI NIH HHS P30 CA021765NIAID NIH HHS U19 AI067773NIAID NIH HHS U19 AI067798
6 · The paper itself

Abstract

Hematopoietic stem and progenitor cells (HSPCs) are predominantly quiescent in adults, but proliferate in response to bone marrow (BM) injury. Here, we show that deletion of Ca

Indexed as

AnimalsBenzimidazolesCalciumCalcium-Calmodulin-Dependent Protein Kinase KinaseCalmodulinGreen Fluorescent ProteinsHematopoietic Stem CellsMiceMice, KnockoutNaphthalimidesRadiation InjuriesRegenerationSignal TransductionWhole-Body IrradiationBenzimidazolesCalciumCalcium-Calmodulin-Dependent Protein Kinase KinaseCalmodulinCamkk2 protein, mouseGreen Fluorescent ProteinsNaphthalimidesSTO 609

Identifiers

PMID28981105
PMCPMC5680595
OpenAlexW2763310628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.