ArticleJournal of perinatology : official journal of the California Perinatal Association2017
Anti-microbial stewardship: antibiotic use in well-appearing term neonates born to mothers with chorioamnionitis.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- A systematic review of Perinatal Antibiotic Stewardship - where we are, where to go?Journal of perinatology : official journal of the California Perinatal Association · 2025Pooled it
- Antimicrobial stewardship in UK special care baby units: gaps in research and future directions.JAC-antimicrobial resistance · 2026Review
- Clinical Outcomes of the Adapted AAP 2019 Guidelines on Early Onset Sepsis in Thailand.Antibiotics (Basel, Switzerland) · 2025Article
- Article
- Antibiotic Treatment for Well-Appearing Infants Born at ≥35 Weeks' Gestation to Mothers with Chorioamnionitis Before and After Implementation of Neonatal Early-Onset Sepsis Calculator.Journal of patient-centered research and reviews · 2024Article
- Fighting Antimicrobial Resistance in Neonatal Intensive Care Units: Rational Use of Antibiotics in Neonatal Sepsis.Antibiotics (Basel, Switzerland) · 2023Review
- Chorioamnionitis and neonatal outcomes.Pediatric research · 2022Review
- Early-onset sepsis risk calculator: a review of its effectiveness and comparative study with our evidence-based local guidelines.Italian journal of pediatrics · 2021Article
- A comparison of Triple I classification with neonatal early-onset sepsis calculator recommendations in neonates born to mothers with clinical chorioamnionitis.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Implementation of an antibiotic stewardship quality improvement initiative in a community hospital for infants born at ≥35 weeks.Proceedings (Baylor University. Medical Center) · 2020Article
- Sensitivity of the Kaiser Permanente early-onset sepsis calculator: A systematic review and meta-analysis.EClinicalMedicine · 2020Article
- Management of Late Preterm and Term Neonates exposed to maternal Chorioamnionitis.BMC pediatrics · 2019Article
- Early onset sepsis calculator-based management of newborns exposed to maternal intrapartum fever: a cost benefit analysis.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Infants Born to Mothers with Clinical Chorioamnionitis: A Cross-Sectional Survey on the Use of Early-Onset Sepsis Risk Calculator and Prolonged Use of Antibiotics.American journal of perinatology · 2019Article
- Induction of labor and early-onset Sepsis guidelines: impact on NICU admissions in Erie County, NY.Maternal health, neonatology and perinatology · 2019Article
- Managing Infants Exposed to Maternal Chorioamnionitis by the Use of Early-Onset Sepsis Calculator.Global pediatric health · 2019Article
- Implementation of the sepsis risk score for chorioamnionitis-exposed newborns.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Does maternal chorioamnionitis have to equal antibiotics in an asymptomatic infant?Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Is early-onset sepsis risk calculator safe for the management of neonates born to mothers with chorioamnionitis?Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Sepsis calculator implementation reduces empiric antibiotics for suspected early-onset sepsis.European journal of pediatrics · 2018Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine if implementation of a protocol based on a neonatal early-onset sepsis (EOS) calculator developed by Kaiser Permanente would safely reduce antibiotic use in well-appearing term infants born to mothers with chorioamnionitis in the unique setting of an Observation Nursery. STUDY
designData obtained from a retrospective chart review of well-appearing term infants born between 2009 and 2016 were entered into the EOS calculator to obtain management recommendations.
resultsThree hundred and sixty-two infants met the study criteria. Management according to the EOS calculator would reduce antibiotic use from 99% to 2.5% (P<0.0001) of patients. Average length of therapy would also decrease from 2.08 to 0.05 days (P<0.0001). One infant, who remained asymptomatic, had Enterococcus bacteremia and received a 7-day course of broad-spectrum antibiotics.
conclusionsCulture-positive sepsis in asymptomatic neonates born to mothers with chorioamnionitis is rare. Management according to the EOS calculator would markedly reduce the potential complications of antibiotic use. These data should initiate re-examination of existing protocols for management of this cohort of patients.
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Registered trials
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