SynthesisGenetics in medicine : official journal of the American College of Medical Genetics2018
Vascular phenotypes in nonvascular subtypes of the Ehlers-Danlos syndrome: a systematic review.
Synthesis in Genetics in medicine : official journal of the American College of Medical Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Vascular aneurysms in Ehlers-Danlos syndrome subtypes: A systematic review.Clinical genetics · 2023Pooled it
- Extracutaneous features and complications of the Ehlers-Danlos syndromes: A systematic review.Frontiers in medicine · 2023Pooled it
- Ehlers-Danlos Syndrome Type Arthrochalasia: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Association between ocular manifestations and incident cardiovascular comorbidities in Ehlers Danlos Syndrome.Eye (London, England) · 2026Article
- Kyphoscoliotic Ehlers-Danlos syndrome due to a novel homozygous PLOD1 variant: severe vascular involvement and molecular diagnosis.BMC medical genomics · 2026Article
- Article
- Interventional varicose vein therapy using endoluminal laser ablation (1940 nm) in patients with Ehlers-Danlos syndromes: two case reports.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Article
- Cardiodermatology: the heart of the connection between the skin and cardiovascular disease.Nature reviews. Cardiology · 2025Review
- Rare vascular complications in classical Ehlers-Danlos syndromes.BMJ case reports · 2025Article
- Kyphoscoliotic Ehlers-Danlos syndrome associated with superior mesenteric artery aneurysm and abdominal aortic rupture: a case report.Frontiers in pediatrics · 2025Article
- Cerebral air embolism associated with cavitary lung lesion in a patient with Ehlers-Danlos syndrome.Radiology case reports · 2024Article
- Spontaneous celiac artery aneurysms in 13-year-old and 10-year-old brothers withJournal of vascular surgery cases and innovative techniques · 2024Article
- Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections.Basic research in cardiology · 2024Review
- Article
- Endovascular treatment of a ruptured aortic pseudoaneurysm and its complications in an 8-year-old child with Ehlers-Danlos syndrome type VI.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- Placing joint hypermobility in context: traits, disorders and syndromes.British medical bulletin · 2023Article
- Retinal arterial tortuosity in Ehlers-Danlos syndromes.Eye (London, England) · 2023Article
- Article
- A severe case ofClinical case reports · 2023Article
- Cardiovascular manifestations of hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders.Vascular medicine (London, England) · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PurposeWithin the spectrum of the Ehlers-Danlos syndromes (EDS), vascular complications are usually associated with the vascular subtype of EDS. Vascular complications are also observed in other EDS subtypes, but the reports are anecdotal and the information is dispersed. To better document the nature of vascular complications among "nonvascular" EDS subtypes, we performed a systematic review.MethodsWe queried three databases for English-language studies from inception until May 2017, documenting both phenotypes and genotypes of patients with nonvascular EDS subtypes. The outcome included the number and nature of vascular complications.ResultsA total of 112 papers were included and data were collected from 467 patients, of whom 77 presented with a vascular phenotype. Severe complications included mainly hematomas (53%), frequently reported in musculocontractural and classical-like EDS; intracranial hemorrhages (18%), with a high risk in dermatosparaxis EDS; and arterial dissections (16%), frequently reported in kyphoscoliotic and classical EDS. Other, more minor, vascular complications were reported in cardiac-valvular, arthrochalasia, spondylodysplastic, and periodontal EDS.ConclusionPotentially life-threatening vascular complications are a rare but important finding in several nonvascular EDS subtypes, highlighting a need for more systematic documentation. This review will help familiarize clinicians with the spectrum of vascular complications in EDS and guide follow-up and management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.