Evidence map›Paper›PMID 28980859›Full record

ReviewAutophagy2018

Ion channels in the regulation of autophagy.

Artem Kondratskyi, Kateryna Kondratska, Roman Skryma, Daniel J Klionsky, Natalia Prevarskaya

Abstract readReview
In one paragraph

Review in Autophagy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

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  17. The plant pathogenic bacteriumMicrobiology spectrum · 2023
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Artem Kondratskyia Inserm, U-1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, University of Lille 1 , Villeneuve d'Ascq , France.ORCID 0000-0003-3290-0524
Kateryna Kondratskaa Inserm, U-1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, University of Lille 1 , Villeneuve d'Ascq , France.
Roman Skrymaa Inserm, U-1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, University of Lille 1 , Villeneuve d'Ascq , France.
Daniel J Klionskyb Life Sciences Institute, and Department of Molecular, Cellular and Developmental Biology ; University of Michigan , Ann Arbor , MI , USA.ORCID 0000-0002-7828-8118
Natalia Prevarskayaa Inserm, U-1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, University of Lille 1 , Villeneuve d'Ascq , France.

Funding

ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEASTR01GM053396 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KLIONSKY, DANIEL J. · 1995 to 2018
$12.1M
NIGMS NIH HHS R01 GM053396
6 · The paper itself

Abstract

Autophagy is a cellular process in which the cell degrades and recycles its own constituents. Given the crucial role of autophagy in physiology, deregulation of autophagic machinery is associated with various diseases. Hence, a thorough understanding of autophagy regulatory mechanisms is crucially important for the elaboration of efficient treatments for different diseases. Recently, ion channels, mediating ion fluxes across cellular membranes, have emerged as important regulators of both basal and induced autophagy. However, the mechanisms by which specific ion channels regulate autophagy are still poorly understood, thus underscoring the need for further research in this field. Here we discuss the involvement of major types of ion channels in autophagy regulation.

Indexed as

AnimalsAutophagyHumansIon ChannelsIon Channelsautophagycalciumchlorideion channelspotassiumsodium

Identifiers

PMID28980859
PMCPMC5846505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.