Evidence map›Paper›PMID 28980852›Full record

ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2017

Mast Cell Mediators Inhibit Osteoblastic Differentiation and Extracellular Matrix Mineralization.

William Marcatti Amarú Maximiano, Elaine Zayas Marcelino da Silva, Ana Carolina Santana, Paulo Tambasco de Oliveira, Maria Célia Jamur, Constance Oliver

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

William Marcatti Amarú MaximianoDepartment of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Elaine Zayas Marcelino da SilvaDepartment of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Ana Carolina SantanaDepartment of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Paulo Tambasco de OliveiraDepartment of Morphology, Stomatology, and Basic Pathology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Maria Célia JamurDepartment of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Constance OliverDepartment of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mast cells are multifunctional immune cells that participate in many important processes such as defense against pathogens, allergic reactions, and tissue repair. These cells perform their functions through the release of a wide variety of mediators. This release occurs mainly through cross-linking IgE (immunoglobulin E) bound to high affinity IgE receptors by multivalent antigens. The abundance of mast cells in connective tissue, surrounding blood vessels, and their involvement in the early stages of bone repair support the possibility of physiological and pathological interactions between mast cells and osteoblasts. However, the participation of mast cell mediators in osteogenesis is not fully understood. Therefore, the objective of this work was to investigate the role of mast cell mediators in the acquisition of the osteogenic phenotype in vitro. The results show that pooled mast cell mediators can affect proliferation, morphology, and cytoskeleton of osteoblastic cells, and impair the activity and expression of alkaline phosphatase as well as the expression of bone sialoprotein. Also, mast cell mediators inhibit the expression of mRNA for those proteins and inhibit the formation and maturation of calcium nodules and consequently inhibit mineralization. Therefore, mast cell mediators can modulate osteogenesis and are potential therapeutic targets for treatments of bone disorders.

Indexed as

Actin CytoskeletonAlkaline PhosphataseAnimalsCell DifferentiationCell LineCell ProliferationExtracellular MatrixGene Expression Regulation, EnzymologicIntegrin-Binding SialoproteinMast CellsMineralsOsteoblastsOsteopontinProtein TransportRatsRNA, MessengerAlkaline PhosphataseIntegrin-Binding SialoproteinMineralsOsteopontinRNA, MessengerAlizarin redbone remodelingcell shapeco-cultureenergy dispersive x-ray spectrometryfluorescence microscopyrat

Identifiers

PMID28980852
PMCPMC5714098
OpenAlexW2764198371

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.