Evidence map›Paper›PMID 28980833›Full record

SynthesisJournal of comparative effectiveness research2018

Handling missing data in propensity score estimation in comparative effectiveness evaluations: a systematic review.

Lucas Malla, Rafael Perera-Salazar, Emily McFadden, Morris Ogero, Kasia Stepniewska, Mike English

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of comparative effectiveness research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Observational
  7. Article
  8. Observational
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lucas MallaNuffield Department of Medicine, University of Oxford, Oxford, UK.
Rafael Perera-SalazarNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Emily McFaddenNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Morris OgeroKenya Medical Research Institute-Wellcome Trust Research Programme, Nairobi, Kenya.
Kasia StepniewskaNuffield Department of Medicine, University of Oxford, Oxford, UK.
Mike EnglishNuffield Department of Medicine, University of Oxford, Oxford, UK.

Funding

Wellcome TrustWellcome Trust 092654Wellcome Trust 097170
6 · The paper itself

Abstract

aimEven though systematic reviews have examined how aspects of propensity score methods are used, none has reviewed how the challenge of missing data is addressed with these methods. This review therefore describes how missing data are addressed with propensity score methods in observational comparative effectiveness studies.

methodsPublished articles on observational comparative effectiveness studies were extracted from MEDLINE and EMBASE databases.

resultsOur search yielded 167 eligible articles. Majority of these studies (114; 68%) conducted complete case analysis with only 53 of them stating this in the methods. Only 16 articles reported use of multiple imputation.

conclusionFew researchers use correct methods for handling missing data or reported missing data methodology which may lead to reporting biased findings.

Indexed as

Propensity ScoreComparative Effectiveness ResearchData CollectionHumansObservational Studies as Topiccomparative effectivenessmissing datapropensity score

Identifiers

PMID28980833
PMCPMC6478118

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.