Evidence map›Paper›PMID 28980755›Full record

ArticleChembiochem : a European journal of chemical biology2017

Protonation-Initiated Cyclization by a Class II Terpene Cyclase Assisted by Tunneling.

Adam Eriksson, Charlotte Kürten, Per-Olof Syrén

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Protonation-Initiated Cyclization by a Class II Terpene Cyclase Assisted by Tunneling.Chembiochem : a European journal of chemical biology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adam ErikssonSchool of Chemical Science and Engineering, KTH Royal Institute of Technology, 100 44, Stockholm, Sweden.ORCID 0000-0003-4780-6274
Charlotte KürtenScience for Life Laboratory, KTH Royal Institute of Technology, School of Biotechnology, Division of Proteomics, 171 21, Stockholm, Sweden.ORCID 0000-0002-1685-4735
Per-Olof SyrénSchool of Chemical Science and Engineering, KTH Royal Institute of Technology, 100 44, Stockholm, Sweden.ORCID 0000-0002-4066-2776

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Terpenes represent one of the most diversified classes of natural products with potent biological activities. The key to the myriad of polycyclic terpene skeletons with crucial functions in organisms from all kingdoms of life are terpene cyclase enzymes. These biocatalysts enable stereospecific cyclization of relatively simple, linear, prefolded polyisoprenes by highly complex, partially concerted, electrophilic cyclization cascades that remain incompletely understood. Herein, additional mechanistic light is shed on terpene biosynthesis by kinetic studies in mixed H

Indexed as

Alkyl and Aryl TransferasesBacterial ProteinsCyclizationDeuterium OxideKineticsProtonsStreptomycesTemperatureTerpenesAlkyl and Aryl TransferasesBacterial ProteinsDeuterium OxideProtonsTerpenesbiosynthesisenzyme catalysisisotope effectskineticsreaction mechanisms

Identifiers

PMID28980755
PMCPMC5725671

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.