ReviewInternational journal of clinical practice2017
Serum testosterone levels in male hypogonadism: Why and when to check-A review.
Review in International journal of clinical practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.Journal of cachexia, sarcopenia and muscle · 2024Trial
- Alternatives to serum testing for transdermal testosterone monitoring: a review of clinical data and correlation with clinical response.Frontiers in reproductive health · 2026Article
- The importance of muscle strength and physical performance as part of the diagnosis and management of sarcopenia in young adults living with human immunodeficiency virus.Archives of endocrinology and metabolism · 2025Article
- Study protocol: associations between hormonal profile and physical and cognitive functions in middle-aged men-a one-year cohort follow-up study.Frontiers in public health · 2025Article
- Testosterone Therapy for Late-Onset Hypogonadism: A Clinical, Biological, and Analytical Approach Using Compounded Testosterone 0.5-20% Topical Gels.Pharmaceutics · 2024Article
- Alpha-pinene neutralizes cisplatin-induced reproductive toxicity in male rats through activation of Nrf2 pathway.International urology and nephrology · 2024Article
- Adult Male Hypogonadism: A Laboratory Medicine Perspective on Its Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2023Review
- Article
- VDR promotes testosterone synthesis in mouse Leydig cells via regulation of cholesterol side chain cleavage cytochrome P450 (Cyp11a1) expression.Genes & genomics · 2023Article
- Expert Opinion on the Diagnosis and Management of Male Hypogonadism in India.International journal of endocrinology · 2023Review
- Association between hypertriglyceridemic waist phenotype and hypogonadism in Taiwanese adult men.PloS one · 2022Article
- Relationship Between Serum Testosterone Levels and Kidney Stones Prevalence in Men.Frontiers in endocrinology · 2022Article
- Hypogonadism and its treatment among prostate cancer survivors.International journal of impotence research · 2021Review
- The Burden of Hormonal Disorders: A Worldwide Overview With a Particular Look in Italy.Frontiers in endocrinology · 2021Review
- Cardiovascular Disease, Hypogonadism and Erectile Dysfunction: Early Detection, Prevention and the Positive Effects of Long-Term Testosterone Treatment: Prospective Observational, Real-Life Data.Vascular health and risk management · 2021Observational
- Secular trends in testosterone- findings from a large state-mandate care provider.Reproductive biology and endocrinology : RB&E · 2020Article
- A review of the evolving landscape between the consumer Internet and men's health.Translational andrology and urology · 2020Review
- Investigating the basis of sexual dysfunction during late-onset hypogonadism.F1000Research · 2019Review
- Sugar-sweetened beverage intake and serum testosterone levels in adult males 20-39 years old in the United States.Reproductive biology and endocrinology : RB&E · 2018Article
- Serum testosterone levels in male hypogonadism: Why and when to check-A review.International journal of clinical practice · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimAlthough "late onset hypogonadism", a condition that includes low testosterone and symptoms, is common in men over the age of 40 years, diagnosis is not clear cut amongst non-specialists. It is the aim of this review to provide an up to date picture of how this state should be diagnosed and managed.
methodsWe aim to describe how primary and secondary hypogonadism should be excluded before the diagnosis of late onset hypogonadism is reached. As laboratory testosterone measurements are essential the current pitfalls such as inappropriate sample collection and the use of population derived reference ranges are expanded. We review current evidence to determine associations between late onset hypogonadism and morbidity/mortality and benefits following testosterone replacement therapy.
resultsA review of the current evidence shows that late onset hypogonadism is associated with a worse metabolic state and increased mortality. Longitudinal studies have suggested that significant reductions in both symptoms and mortality are seen, especially in patients with type 2 diabetes. DISCUSSION: This review highlights the importance of diagnosing late onset hypogonadism due to its association with morbidity/mortality and benefits following testosterone replacement. Thus, after making recommendations to ensure correct diagnosis we speculate whether the time has come to move away from population derived testosterone levels towards evidence based action limits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.